Curriculum
- 22 Sections
- 861 Lessons
- 10 Weeks
Expand all sectionsCollapse all sections
- U01.01 BiochemistryThis biochemistry review for USMLE Step 1 covers essential topics including metabolism, enzymology, and molecular biology.136
- 1.1U01.01.001 Chromatin structure
- 1.2U01.01.002 Nucleotides
- 1.3U01.01.003 De novo pyrimidine and purine synthesis
- 1.4U01.01.004 Purine salvage deficiencies
- 1.5U01.01.005 Genetic code features
- 1.6U01.01.006 DNA replication
- 1.7U01.01.007 DNA repair
- 1.8U01.01.008 Mutations in DNA
- 1.9U01.01.009 Lac operon
- 1.10U01.01.010 Functional organization of a eukaryotic gene
- 1.11U01.01.011 Regulation of gene expression
- 1.12U01.01.012 RNA processing (eukaryotes)
- 1.13U01.01.013 RNA polymerases
- 1.14U01.01.014 Introns vs exons
- 1.15U01.01.015 Splicing of pre-mRNA
- 1.16U01.01.016 tRNA
- 1.17U01.01.017 Start and stop codons
- 1.18U01.01.018 Protein synthesis
- 1.19U01.01.019 Posttranslational modifications
- 1.20U01.01.020 Chaperone protein
- 1.21U01.01.021 Cell cycle phases
- 1.22U01.01.022 Rough endoplasmic reticulum
- 1.23U01.01.023 Smooth endoplasmic reticulum
- 1.24U01.01.024 Cell trafficking
- 1.25U01.01.025 Peroxisome
- 1.26U01.01.026 Proteasome
- 1.27U01.01.027 Cytoskeletal elements
- 1.28U01.01.028 Microtubule
- 1.29U01.01.029 Cilia structure
- 1.30U01.01.030 Primary ciliary dyskinesia
- 1.31U01.01.031 Sodium-potassium pump
- 1.32U01.01.032 Collagen
- 1.33U01.01.033 Collagen synthesis and structure
- 1.34U01.01.034 Osteogenesis imperfecta
- 1.35U01.01.035 Ehlers-Danlos syndrome
- 1.36U01.01.036 Menkes disease
- 1.37U01.01.037 Elastin
- 1.38U01.01.038 Marfan syndrome
- 1.39U01.01.039 Homocystinuria
- 1.40U01.01.040 Polymerase chain reaction
- 1.41U01.01.041 CRISPR/Cas9
- 1.42U01.01.042 Blotting Procedures
- 1.43U01.01.043 Flow cytometry
- 1.44U01.01.044 Microarrays
- 1.45U01.01.045 Enzyme-linked immunosorbent assay
- 1.46U01.01.046 Karyotyping
- 1.47U01.01.047 Fluorescence in situ hybridization
- 1.48U01.01.048 Molecular cloning
- 1.49U01.01.049 Gene expression modifications
- 1.50U01.01.050 Genetic terms
- 1.51U01.01.051 Population genetics
- 1.52U01.01.052 Hardy-Weinberg population genetics
- 1.53U01.01.053 Disorders of imprinting
- 1.54U01.01.054 Modes of inheritance
- 1.55U01.01.055 Autosomal dominant diseases
- 1.56U01.01.056 Autosomal recessive diseases
- 1.57U01.01.057 Cystic fibrosis
- 1.58U01.01.058 X-linked recessive disorders
- 1.59U01.01.059 Muscular dystrophies
- 1.60U01.01.060 Mitochondrial Diseases
- 1.61U01.01.061 Rett syndrome
- 1.62U01.01.062 Fragile X syndrome
- 1.63U01.01.063 Trinucleotide repeat expansion diseases
- 1.64U01.01.064 Autosomal trisomies
- 1.65U01.01.065 Genetic disorders by chromosome
- 1.66U01.01.066 Robertsonian translocation
- 1.67U01.01.067 Cri-du-chat syndrome
- 1.68U01.01.068 Williams syndrome
- 1.69U01.01.069 Essential fatty acids
- 1.70U01.01.070 Vitamins: fat soluble
- 1.71U01.01.071 Vitamins: Water soluble
- 1.72U01.01.072 Dietary supplementation
- 1.73U01.01.073 Vitamin A
- 1.74U01.01.074 Vitamin B1
- 1.75U01.01.075 Vitamin B2
- 1.76U01.01.076 Vitamin B3
- 1.77U01.01.077 Vitamin B5
- 1.78U01.01.078 Vitamin B6
- 1.79U01.01.079 Vitamin B7
- 1.80U01.01.080 Vitamin B9
- 1.81U01.01.081 Vitamin B12
- 1.82U01.01.082 Vitamin C
- 1.83U01.01.083 Vitamin D
- 1.84U01.01.084 Vitamin E
- 1.85U01.01.085 Vitamin K
- 1.86U01.01.086 Zinc
- 1.87U01.01.087 Protein-energy malnutrition
- 1.88U01.01.088 Ethanol metabolism
- 1.89U01.01.089 Enzyme terminology
- 1.90U01.01.090 Rate-determining enzymes of metabolic processes
- 1.91U01.01.091 Metabolic compartmentation
- 1.92U01.01.092 Summary of pathways
- 1.93U01.01.093 Activated carriers
- 1.94U01.01.094 Universal electron acceptors
- 1.95U01.01.095 Hexokinase vs glucokinase
- 1.96U01.01.096 Glycolysis regulation
- 1.97U01.01.097 Regulation by fructose-2,6- bisphosphate
- 1.98U01.01.098 Pyruvate dehydrogenase complex
- 1.99U01.01.099 Pyruvate dehydrogenase complex deficiency
- 1.100U01.01.100 Pyruvate metabolism
- 1.101U01.01.101 TCA cycle
- 1.102U01.01.102 Electron transport chain and oxidative phosphorylation
- 1.103U01.01.103 Gluconeogenesis, irreversible enzymes
- 1.104U01.01.104 Pentose phosphate pathway
- 1.105U01.01.105 Glucose-6-phosphate dehydrogenase deficiency
- 1.106U01.01.106 Disorders of fructose metabolism
- 1.107U01.01.107 Disorders of galactose metabolism
- 1.108U01.01.108 Sorbitol
- 1.109U01.01.109 Lactase deficiency
- 1.110U01.01.110 Amino acids
- 1.111U01.01.111 Urea cycle
- 1.112U01.01.112 Transport of ammonia by alanine
- 1.113U01.01.113 Hyperammonemia
- 1.114U01.01.114 Ornithine transcarbamylase deficiency
- 1.115U01.01.115 Amino acid derivatives
- 1.116U01.01.116 Catecholamine synthesis/tyrosine catabolism
- 1.117U01.01.117 Phenylketonuria
- 1.118U01.01.118 Maple syrup urine disease
- 1.119U01.01.119 Alkaptonuria
- 1.120U01.01.120 Homocystinuria
- 1.121U01.01.121 Cystinuria
- 1.122U01.01.122 Organic acidemias
- 1.123U01.01.123 Glycogen regulation by insulin and glucagon/epinephrine
- 1.124U01.01.124 Glycogen
- 1.125U01.01.125 Glycogen storage diseases
- 1.126U01.01.126 Lysosomal storage diseases
- 1.127U01.01.127 Fatty acid metabolism
- 1.128U01.01.128 Ketone bodies
- 1.129U01.01.129 Fasted vs fed state
- 1.130U01.01.130 Metabolic fuel use
- 1.131U01.01.132 Key enzymes in lipid transport
- 1.132U01.01.131 Lipid transport
- 1.133U01.01.133 Major apolipoproteins
- 1.134U01.01.134 Lipoprotein functions
- 1.135U01.01.135 Abetalipoproteinemia
- 1.136U01.01.136 Familial dyslipidemias
- U01.02 ImmunologyPrepare for USMLE Step 1 Immunology with a comprehensive review covering foundational concepts, immune system mechanisms, and key disorders to solidify your understanding and boost exam readiness.39
- 2.1U01.02.001 Immune system organs
- 2.2U01.02.002 Lymph node
- 2.3U01.02.003 Lymphatic drainage associations
- 2.4U01.02.004 Spleen
- 2.5U01.02.005 Thymus
- 2.6U01.02.006 Innate vs adaptive immunity
- 2.7U01.02.007 Immune privilege
- 2.8U01.02.008 Major histocompatibility complex I and II
- 2.9U01.02.009 HLA subtypes associated with diseases
- 2.10U01.02.010 Natural killer cells
- 2.11U01.02.011 Major functions of B and T cells
- 2.12U01.02.012 Differentiation of T Cells
- 2.1301.02.013 Macrophage–Lymphocyte Interaction (Th1–Macrophage Axis)
- 2.1401.02.014 Cytotoxic T cell
- 2.15U01.02.015 Regulatory T cells
- 2.16U01.02.016 T- and B-cell activation
- 2.17U01.02.017 Anergy
- 2.18U01.02.018 Antibody Structure and Function
- 2.19U01.02.019 Immunoglobulin Isotypes
- 2.20U01.02.020 Antigen Type and Immunologic Memory
- 2.21U01.02.021 Complement System
- 2.22U01.02.022 Complement disorders
- 2.23U01.02.023 Cytokines
- 2.24U01.02.024 Respiratory Burst
- 2.25U01.02.025 Type I Interferons (IFN-α, IFN-β)
- 2.26U01.02.026 Cell Surface Proteins
- 2.27U01.02.027 Passive vs active immunity
- 2.28U01.02.028 Vaccination
- 2.29U01.02.029 Hypersensitivity types
- 2.30U01.02.030 Blood transfusion reactions
- 2.31U01.02.031 Autoantibodies
- 2.32U01.02.032 Immunodeficiencies: B-cell disorders
- 2.33U01.02.033 Immunodeficiencies: T-cell disorders
- 2.34U01.02.034 Immunodeficiencies B- & T- cell disorders
- 2.35U01.02.035 Immunodeficiencies Phagocyte dysfunction
- 2.36U01.02.036 Infections in immunodeficiency
- 2.37U01.02.037 Transplant rejection
- 2.38U01.02.038 Immunosuppressants
- 2.39U01.02.039 Recombinant cytokines and clinical uses
- U01.03 MicrobiologyReview essential microbiology topics for the USMLE Step 1, covering key pathogens, mechanisms of disease, and antimicrobial principles critical for mastering infectious disease concepts.183
- 3.1U01.03.001 Bacterial structures
- 3.2U01.03.002 Cell envelope
- 3.3U01.03.003 Stains
- 3.4U01.03.004 Growth media
- 3.5U01.03.005 Anaerobes
- 3.6U01.03.006 Intracellular bacteria
- 3.7U01.03.007 Encapsulated bacteria
- 3.8U01.03.008 Urease-positive organisms
- 3.9U01.03.009 Catalase-positive organisms
- 3.10U01.03.010 Pigment producing bacteria
- 3.11U01.03.011 Biofilm producing bacteria
- 3.12U01.03.012 Spore forming bacteria
- 3.13U01.03.013 Bacterial virulence factor
- 3.14U01.03.014 Antibiotic resistance mechanisms
- 3.15U01.03.015 Bacterial genetics
- 3.16U01.03.016 Features of exotoxins and endotoxins
- 3.17U01.03.017 Bacteria with exotoxins
- 3.18U01.03.018 Bacterial endotoxin
- 3.19U01.03.019 Gram-positive lab algorithm
- 3.20U01.03.020 Hemolytic Bacteria
- 3.21U01.03.021 Staphylococcus aureus
- 3.22U01.03.022 Staphylococcus epidermidis
- 3.23U01.03.023 Staphylococcus saprophyticus
- 3.24U01.03.024 Streptococcus pneumoniae
- 3.25U01.03.025 Viridans group streptococci
- 3.26U01.03.026 Streptococcus pyogenes (group A streptococci)
- 3.27U01.03.027 Streptococcus agalactiae (group B streptococci)
- 3.28U01.03.028 Streptococcus gallolyticus
- 3.29U01.03.029 Enterococci
- 3.30U01.03.030 Bacillus anthracis
- 3.31U01.03.031 Bacillus cereus
- 3.32U01.03.032 Clostridioides difficile
- 3.33U01.03.033 Clostridium tetani
- 3.34U01.03.034 Clostridium botulinum
- 3.35U01.03.035 Clostridium perfringens
- 3.36U01.03.036 Corynebacterium diphtheriae
- 3.37U01.03.037 Listeria monocytogenes
- 3.38U01.03.038 Nocardia
- 3.39U01.03.039 Actinomyces
- 3.40U01.03.040 Mycobacteria
- 3.41U01.03.041 Tuberculosis
- 3.42U01.03.042 Leprosy
- 3.43U01.03.043 Gram-negative lab algorithm
- 3.44U01.03.044 Neisseria
- 3.45U01.03.045 Haemophilus influenzae
- 3.46U01.03.046 Burkholderia cepacia complex
- 3.47U01.03.047 Bordetella pertussis
- 3.48U01.03.048 Brucella
- 3.49U01.03.049 Legionella pneumophila
- 3.50U01.03.050 Pseudomonas aeruginosa
- 3.51U01.03.051 Salmonella
- 3.52U01.03.052 Shigella
- 3.53U01.03.053 Yersinia enterocolitica
- 3.54U01.03.054 Lactose-fermenting enteric bacteria
- 3.55U01.03.055 Escherichia coli
- 3.56U01.03.056 Klebsiella
- 3.57U01.03.057 Campylobacter jejuni
- 3.58U01.03.058 Proteus mirabilis
- 3.59U01.03.059 Vibrio cholerae
- 3.60U01.03.060 Helicobacter pylori
- 3.61U01.03.061 Spirochetes A
- 3.62U01.03.062 Lyme disease
- 3.63U01.03.063 Leptospira interrogans
- 3.64U01.03.064 Syphilis
- 3.65U01.03.065 Diagnosing syphilis
- 3.66U01.03.066 Chlamydiae
- 3.67U01.03.067 Chlamydia trachomatis serotypes
- 3.68U01.03.068 Gardnerella vaginalis
- 3.69U01.03.069 Zoonotic bacteria
- 3.70U01.03.070 Rickettsial diseases and vector-borne illnesses
- 3.71U01.03.071 Mycoplasma pneumoniae
- 3.72U01.03.072 Systemic mycoses
- 3.73U01.03.073 Opportunistic fungal infections
- 3.74U01.03.074 Pneumocystis jirovecii
- 3.75U01.03.075 Sporothrix schenckii
- 3.76U01.03.076 Protozoa: Gastrointestinal infections
- 3.77U01.03.077 Protozoa: CNS infections
- 3.78U01.03.078 Protozoa: Hematologic infections
- 3.79U01.03.079 Protozoa: Others
- 3.80U01.03.080 Nematode routes of infection
- 3.81U01.03.081 Nematodes (roundworms)
- 3.82U01.03.082 Cestodes (tapeworms)
- 3.83U01.03.083 Trematodes (flukes)
- 3.84U01.03.084 Ectoparasites
- 3.85U01.03.085 Viral structure—general features
- 3.86U01.03.086 Viral genetics
- 3.87U01.03.087 Viral genomes
- 3.88U01.03.088 Viral envelopes
- 3.89U01.03.089 DNA viruses
- 3.90U01.03.090 Herpesviruses
- 3.91U01.03.091 HSV identification
- 3.92U01.03.092 Receptors used by viruses
- 3.93U01.03.093 RNA viruses
- 3.94U01.03.094 Picornavirus
- 3.95U01.03.095 Rhinovirus
- 3.96U01.03.096 Rotavirus A
- 3.97U01.03.097 Influenza viruses
- 3.98U01.03.099 Rubella virus
- 3.99U01.03.098 Paramyxoviruses
- 3.100U01.03.100 Acute laryngotracheobronchitis
- 3.101U01.03.101 Measles (rubeola) virus
- 3.102U01.03.102 Mumps virus
- 3.103U01.03.103 Arboviruses transmitted by Aedes mosquitoes
- 3.104U01.03.104 Yellow fever virus
- 3.105U01.03.105 Zika virus
- 3.106U01.03.106 Rabies virus
- 3.107U01.03.107 Ebola virus
- 3.108U01.03.108 Severe acute respiratory syndrome coronavirus 2
- 3.109U01.03.109 Hepatitis viruses
- 3.110U01.03.110 Extrahepatic manifestations of hepatitis B and C
- 3.111U01.03.111 Hepatitis serologic markers
- 3.112U01.03.112 HIV
- 3.113U01.03.113 HIV diagnosis
- 3.114U01.03.114 Common diseases of HIV-positive adults
- 3.115U01.03.115 Prions
- 3.116U01.03.116 Normal microbiota: dominant
- 3.117U01.03.117 Bugs causing foodborne illness
- 3.118U01.03.118 Bugs causing diarrhea
- 3.119U01.03.119 Common causes of pneumonia
- 3.120U01.03.120 Common causes of meningitis
- 3.121U01.03.121 Cerebrospinal fluid findings in meningitis
- 3.122U01.03.122 Infections causing brain abscess
- 3.123U01.03.123 Osteomyelitis
- 3.124U01.03.124 Red rashes of childhood
- 3.125U01.03.125 Urinary tract infections
- 3.126U01.03.126 Common vaginal infections
- 3.127U01.03.127 Sexually transmitted infections
- 3.128U01.03.128 TORCH infections
- 3.129U01.03.129 Pelvic inflammatory disease
- 3.130U01.03.130 Healthcare-associated infections
- 3.131U01.03.131 Bugs affecting unvaccinated children
- 3.132U01.03.132 Antimicrobial therapy
- 3.133U01.03.133 Penicillin G, V
- 3.134U01.03.134 Penicillinase-sensitive penicillins
- 3.135U01.03.136 Piperacillin
- 3.136U01.03.135 Penicillinase-resistant penicillins
- 3.137U01.03.137 Cephalosporins
- 3.138U01.03.138 ß -lactamase inhibitors
- 3.139U01.03.139 Carbapenems
- 3.140U01.03.140 Aztreonam
- 3.141U01.03.141 Vancomycin
- 3.142U01.03.142 Protein synthesis inhibitors
- 3.143U01.03.143 Aminoglycosides
- 3.144U01.03.144 Tetracyclines
- 3.145U01.03.145 Tigecycline
- 3.146U01.03.146 Chloramphenicol
- 3.147U01.03.147 Clindamycin
- 3.148U01.03.148 Linezolid
- 3.149U01.03.149 Macrolides
- 3.150U01.03.150 Polymyxins
- 3.151U01.03.151 Sulfonamides
- 3.152U01.03.152 Dapsone
- 3.153U01.03.153 Trimethoprim
- 3.154U01.03.154 Fluoroquinolones
- 3.155U01.03.155 Daptomycin
- 3.156U01.03.156 Metronidazole
- 3.157U01.03.157 Antituberculous drugs
- 3.158U01.03.158 Antimycobacterial therapy
- 3.159U01.03.159 Antimicrobial prophylaxis
- 3.160U01.03.160 Prophylaxis in HIV infection/AIDS
- 3.161U01.03.161 Antifungal therapy
- 3.162U01.03.162 Amphotericin B
- 3.163U01.03.163 Nystatin
- 3.164U01.03.164 Flucytosine
- 3.165U01.03.165 Azoles
- 3.166U01.03.166 Terbinafine
- 3.167U01.03.167 Echinocandins
- 3.168U01.03.168 Griseofulvin
- 3.169U01.03.169 Antiprotozoal therapy
- 3.170U01.03.170 Anti-mite/louse therapy
- 3.171U01.03.171 Chloroquine
- 3.172U01.03.172 Antihelminthic therapy
- 3.173U01.03.173 Oseltamivir, zanamivir
- 3.174U01.03.174 Baloxavir
- 3.175U01.03.175 Remdesivir
- 3.176U01.03.176 Acyclovir, famciclovir, valacyclovir
- 3.177U01.03.177 Ganciclovir
- 3.178U01.03.178 Foscarnet
- 3.179U01.03.179 Cidofovir
- 3.180U01.03.180 HIV therapy
- 3.181U01.03.181 Hepatitis C therapy
- 3.182U01.03.182 Disinfection and sterilization
- 3.183U01.03.183 Antimicrobials to avoid in pregnancy
- U01.04 General PathologyExplore key concepts in general pathology essential for the USMLE Step 1. This review covers fundamental principles, disease mechanisms, and clinical correlations to help you excel in your medical exam.38
- 4.1U01.04.001 Cellular adaptations
- 4.2U01.04.002 Cell injury
- 4.3U01.04.003 Apoptosis
- 4.4U01.04.004 Necrosis
- 4.5U01.04.005 Ischemia
- 4.6U01.04.006 Types of infarcts
- 4.7U01.04.007 Free radical injury
- 4.8U01.04.008 Types of calcification
- 4.9U01.04.009 Psammoma Bodies
- 4.10U01.04.010 Amyloidosis
- 4.11U01.04.011 Inflammation
- 4.12U01.04.012 Acute phase reactants
- 4.13U01.04.013 Erythrocyte sedimentation rate
- 4.14U01.04.014 Acute inflammation
- 4.15U01.04.015 Leukocyte extravasation
- 4.16U01.04.016 Chronic inflammation
- 4.17U01.04.017 Wound healing
- 4.18U01.04.018 Granulomatous inflammation
- 4.19U01.04.019 Scar formation
- 4.20U01.04.020 Neoplasia and neoplastic progression
- 4.21U01.04.021 Tumor nomenclature
- 4.22U01.04.022 Tumor grade vs stage
- 4.23U01.04.023 Hallmarks of cancer
- 4.24U01.04.024 Immune checkpoint interactions
- 4.25U01.04.025 Cancer epidemiology
- 4.26U01.04.026 Common metastases
- 4.27U01.04.027 Oncogenes
- 4.28U01.04.028 Tumor suppressor genes
- 4.29U01.04.029 Carcinogens
- 4.30U01.04.030 Oncogenic microbes
- 4.31U01.04.031 Serum tumor markers
- 4.32U01.04.031 Serum tumor markers
- 4.33U01.04.032 Liquid biopsy
- 4.34U01.04.033 Immunohistochemical stains
- 4.35U01.04.034 P-glycoprotein
- 4.36U01.04.035 Paraneoplastic syndromes
- 4.37U01.04.036 Normal aging
- 4.38U01.04.037 Lipofuscin
- U01.05 PharmacologyMaster key pharmacology concepts for the USMLE Step 1 with a focus on drug mechanisms, therapeutic uses, adverse effects, and interactions essential for high-yield exam performance.42
- 5.1U01.05.001 Enzyme kinetics
- 5.2U01.05.002 Pharmacokinetics
- 5.3U01.05.003 Dosage calculation
- 5.4U01.05.004 Drug metabolism
- 5.5U01.05.005 Elimination of drugs
- 5.6U01.05.006 Urine pH and drug elimination
- 5.7U01.05.007 Efficacy vs potency
- 5.8U01.05.008 Receptor binding
- 5.9U01.05.009 Therapeutic index
- 5.10U01.05.010 Types of drug interactions
- 5.11U01.05.011 Autonomic receptors
- 5.12U01.05.012 Acetylcholine receptors
- 5.13U01.05.013 Pain transmission
- 5.14U01.05.014 Micturition control
- 5.15U01.05.015 Tissue distribution of adrenergic receptors
- 5.16U01.05.016 G-protein–linked second messengers
- 5.17U01.05.017 Autonomic drugs
- 5.18U01.05.018 Cholinomimetic agents
- 5.19U01.05.019 Anticholinesterase poisoning
- 5.20U01.05.020 Muscarinic antagonists
- 5.21U01.05.021 Atropine
- 5.22U01.05.022 Sympathomimetics
- 5.23U01.05.023 Physiologic effects of sympathomimetics
- 5.24U01.05.024 Sympatholytics (2-agonists)
- 5.25U01.05.025 ɑ-blockers
- 5.26U01.05.026 ß-blockers
- 5.27U01.05.027 Phosphodiesterase inhibitors
- 5.28U01.05.028 Ingested seafood toxins
- 5.29U01.05.029 Age-related changes in pharmacokinetics
- 5.30U01.05.030 Specific toxicity treatments
- 5.31U01.05.031 Drug reactions: Cardiovascular
- 5.32U01.05.032 Drug reactions: Endocrine/reproductive
- 5.33U01.05.033 Drug reactions—gastrointestinal
- 5.34U01.05.034 Drug reactions—hematologic
- 5.35U01.05.035 Drug reactions—musculoskeletal/skin/connective tissue
- 5.36U01.05.036 Drug reactions—neurologic
- 5.37U01.05.037 Drug reactions—renal/genitourinary
- 5.38U01.05.038 Drug reactions—respiratory
- 5.39U01.05.039 Drug reactions—multiorgan
- 5.40U01.05.040 Drugs affecting pupil size
- 5.41U01.05.041 Cytochrome P-450 interactions
- 5.42U01.05.042 Sulfa drugs
- U01.06 Public Health SciencesReview essential Public Health Sciences topics for the USMLE Step 1, covering epidemiology, biostatistics, health policy, and ethics to strengthen your understanding of foundational public health principles.59
- 6.1U01.06.010 Receiving operating characteristic curve
- 6.2U01.06.011 Precision vs accuracy
- 6.3U01.06.012 Incidence vs prevalence
- 6.4U01.06.013 Bias and study errors
- 6.5U01.06.014 Confounding vs effect modification
- 6.6U01.06.015 Statistical distribution
- 6.7U01.06.016 Statistical hypotheses
- 6.8U01.06.017 Outcomes of statistical hypothesis testing
- 6.9U01.06.018 tatistical vs clinical significance
- 6.10U01.06.019 Confidence interval
- 6.11U01.06.020 Meta-analysis
- 6.12U01.06.021 Common statistical tests
- 6.13U01.06.022 Pearson correlation coefficient
- 6.14U01.06.023 Core ethical principles
- 6.15U01.06.024 Decision-making capacity
- 6.16U01.06.025 Informed consent
- 6.17U01.06.026 Consent for minors
- 6.18U01.06.027 Advance directives
- 6.19U01.06.028 Ventilator-assisted life support
- 6.20U01.06.029 Surrogate decisionmaker
- 6.21U01.06.030 Confidentiality
- 6.22U01.06.031 Accepting gifts from patients
- 6.23U01.06.032 Patient-centered interviewing techniques
- 6.24U01.06.033 Establishing rapport
- 6.25U01.06.034 Delivering bad news
- 6.26U01.06.035 Gender- and sexualityinclusive history taking
- 6.27U01.06.036 Cultural formulation interview
- 6.28U01.06.037 Motivational interviewing
- 6.29U01.06.038 Trauma-informed care
- 6.30U01.06.039 Challenging patient and ethical scenarios
- 6.31U01.06.040 Communicating with patients with disabilities
- 6.32U01.06.041 Use of interpreters
- 6.33U01.06.042 Disease prevention
- 6.34U01.06.043 Major medical insurance plans
- 6.35U01.06.044 Healthcare payment models
- 6.36U01.06.045 Medicare and Medicaid
- 6.37U01.06.046 Hospice care
- 6.38U01.06.047 Types of medical errors
- 6.39U01.06.0 48 Medical error analysis
- 6.40U01.06.049 Burnout vs fatigue
- 6.41U01.06.049 Burnout vs fatigue
- 6.42U01.06.050 Safety culture
- 6.43U01.06.051 Human factors design
- 6.44U01.06.052 PDSA cycle
- 6.45U01.06.053 Quality measurements
- 6.46U01.06.054 Swiss cheese model
- 6.47U01.06.055 Changes in the elderly
- 6.48U01.06.056 Common causes of death (US) by age
- 6.49U01.06.057 Conditions with frequent hospital readmissions
- 6.50U01.06.001 Observational studies
- 6.51U01.06.002 Clinical trial
- 6.52U01.06.003 Off-label drug use
- 6.53U01.06.004 Bradford Hill criteria
- 6.54U01.06.005 Quantifying risk
- 6.55U01.06.006 Demographic transition
- 6.56U01.06.007 Kaplan–Meier Curve
- 6.57U01.06.008 Evaluation of diagnostic tests
- 6.58U01.06.009 Likelihood ratio
- 6.59U01.06.010 Receiving operating characteristic curve
- U01.07 Cardiovascular systemComprehensive review of essential cardiovascular system topics to help you excel in the USMLE Step 1 exam, covering key concepts from anatomy to pathology.67
- 7.1U01.07.031 Congenital heart diseases45 Minutes
- 7.2U01.07.032 Congenital cardiac defect associations25 Minutes
- 7.3U01.07.033 Hypertension30 Minutes
- 7.4U01.07.034 Hyperlipidemia25 Minutes
- 7.5U01.07.035 Arteriosclerosis30 Minutes
- 7.6U01.07.036 Atherosclerosis30 Minutes
- 7.7U01.07.037 Aortic aneurysm30 Minutes
- 7.8U01.07.038 Traumatic aortic rupture20 Minutes
- 7.9U01.07.039 Aortic dissection30 Minutes
- 7.10U01.07.040 Ischemic heart disease manifestations40 Minutes
- 7.11U01.07.041 Evolution of myocardial infarction25 Minutes
- 7.12U01.07.042 Diagnosis of myocardial infarction20 Minutes
- 7.13U01.07.043 ECG localization of STEMI25 Minutes
- 7.14U01.07.044 Myocardial infarction complications35 Minutes
- 7.15U01.07.045 Acute coronary syndrome treatments30 Minutes
- 7.16U01.07.046 Cardiomyopathies35 Minutes
- 7.17U01.07.047 Heart failure30 Minutes
- 7.18U01.07.048 Shock25 Minutes
- 7.19U01.07.049 Cardiac tamponade20 Minutes
- 7.20U01.07.050 Bacterial endocarditis30 Minutes
- 7.21U01.07.051 Rheumatic fever35 Minutes
- 7.22U01.07.052 Syphilitic heart disease30 Minutes
- 7.23U01.07.053 Acute pericarditis30 Minutes
- 7.24U01.07.054 Myocarditis25 Minutes
- 7.25U01.07.055 Vasculitides60 Minutes
- 7.26U01.07.056 Cardiac tumors30 Minutes
- 7.27U01.07.057 Kussmaul sign30 Minutes
- 7.28U01.07.058 Hereditary hemorrhagic telangiectasia20 Minutes
- 7.29U01.07.059 Hypertension treatment25 Minutes
- 7.30U01.07.060 Hydralazine25 Minutes
- 7.31U01.07.061 Hypertensive emergencies25 Minutes
- 7.32U01.07.062 Nitrates25 Minutes
- 7.33U01.07.063 Ranolazine15 Minutes
- 7.34U01.07.064 Sacubitril15 Minutes
- 7.35U01.07.065 Antianginal therapy40 Minutes
- 7.36U01.07.066 Lipid-lowering agents60 Minutes
- 7.37U01.07.067 Cardiac glycosides30 Minutes
- 7.38U01.07.068 Antiarrhythmics— sodium channel blockers (class I)30 Minutes
- 7.39U01.07.069 Antiarrhythmics— β-blockers (class II)30 Minutes
- 7.40U01.07.070 Antiarrhythmics— potassium channel blockers (class III)30 Minutes
- 7.41U01.07.071 Antiarrhythmics— calcium channel blockers (class IV)40 Minutes
- 7.42U01.07.072 Other antiarrhythmics30 Minutes
- 7.43U01.07.001 Heart morphogenesis
- 7.44U01.07.002 Heart embryology
- 7.45U01.07.003 Fetal-postnatal derivatives
- 7.46U01.07.004 Fetal circulation
- 7.47U01.07.005 Anatomy of the heart
- 7.48U01.07.006 Cardiac output variables
- 7.49U01.07.007 Cardiac output equations
- 7.50U01.07.008 Starling curves
- 7.51U01.07.009 Resistance, pressure, flow
- 7.52U01.07.010 Cardiac and vascular function curves
- 7.53U01.07.011 Pressure-volume loops and cardiac cycle
- 7.54U01.07.012 Jugular venous pressure tracings
- 7.55U01.07.013 Pressure-volume loops and valvular disease
- 7.56U01.07.014 Splitting of S2
- 7.57U01.07.015 Auscultation of the heart
- 7.58U01.07.016 Heart murmurs
- 7.59U01.07.017 Myocardial action potential
- 7.60U01.07.018 Pacemaker
- 7.61U01.07.019 Electrocardiogram
- 7.62U01.07.020 Atrial natriuretic peptide
- 7.63U01.07.021 B-type (brain) natriuretic peptide
- 7.64U01.07.022 Baroreceptors and chemoreceptors
- 7.65U01.07.023 Normal cardiac pressures
- 7.66U01.07.024 Auto-regulation
- 7.67U01.07.025 Capillary fluid exchange
- U01.08 Endocrine systemMaster essential concepts of the endocrine system for USMLE Step 1, covering hormone regulation, feedback mechanisms, and key disorders to boost your exam readiness.56
- 8.1U01.08.01 Thyroid development
- 8.2U01.08.02 Pituitary Gland
- 8.3U01.08.03 Adrenal cortex and medulla
- 8.4U01.08.04 Endocrine pancreas cell types
- 8.5U01.08.05 Hypothalamic-Pituitary Hormones
- 8.6U01.08.06 Growth hormone
- 8.7U01.08.07 Antidiuretic hormone
- 8.8U01.08.008 Prolactin
- 8.9U01.08.009 Thyroid hormones
- 8.10U01.08.010 Parathyroid hormone
- 8.11U01.08.011 Calcium homeostasis
- 8.12U01.08.012 Calcitonin
- 8.13U01.08.013 Glucagon
- 8.14U01.08.014 Insulin
- 8.15U01.08.015 Adrenal steroids and congenital adrenal hyperplasias
- 8.16U01.08.016 Cortisol
- 8.17U01.08.017 Appetite regulation
- 8.18U01.08.018 Signaling pathways of endocrine hormones
- 8.19U01.08.019 Signaling pathways of steroid hormones
- 8.20U01.08.020 Syndrome of inappropriate antidiuretic hormone secretion
- 8.21U01.08.021 Primary polydipsia and diabetes insipidus
- 8.22U01.08.022 Hypopituitarism
- 8.23U01.08.023 Acromegaly
- 8.24U01.08.024 Hypothyroidism vs hyperthyroidism
- 8.25U01.08.025 Hypothyroidism
- 8.26U01.08.026 Hyperthyroidism
- 8.27U01.08.027 Causes of goiter
- 8.28U01.08.028 Thyroid adenoma
- 8.29U01.08.029 Thyroid cancer
- 8.30U01.08.030 Diagnosing parathyroid disease
- 8.31U01.08.031 Hypoparathyroidism
- 8.32U01.08.032 Lab values in hypocalcemic disorders
- 8.33U01.08.033 Hyperparathyroidism
- 8.34U01.08.034 Familial hypocalciuric hypercalcemia
- 8.35U01.08.035 Diabetes mellitus
- 8.36U01.08.036 Type 1 vs type 2 diabetes mellitus
- 8.37U01.08.037 Hyperglycemic emergencies
- 8.38U01.08.038 Hypoglycemia in diabetes mellitus
- 8.39U01.08.039 Cushing syndrome
- 8.40U01.08.040 Adrenal insufficiency
- 8.41U01.08.041 Hyperaldosteronism
- 8.42U01.08.042 Neuroendocrine tumors
- 8.43U01.08.043 Neuroblastoma
- 8.44U01.08.044 Pheochromocytoma
- 8.45U01.08.045 Multiple endocrine neoplasias
- 8.46U01.08.046 Pancreatic islet cell tumors
- 8.47U01.08.047 Carcinoid tumors
- 8.48U01.08.048 Zollinger-Ellison syndrome
- 8.49U01.08.049 Diabetes mellitus therapy
- 8.50U01.08.050 Thionamides
- 8.51U01.08.051 Levothyroxine, liothyronine
- 8.52U01.08.052 Hypothalamic/pituitary drugs
- 8.53U01.08.053 Fludrocortisone
- 8.54U01.08.054 Cinacalcet
- 8.55U01.08.055 Sevelamer
- 8.56U01.08.056 Cation exchange resins
- U01.09 Gastrointestinal systemReview key topics in the gastrointestinal system for the USMLE Step 1, covering essential concepts in anatomy, physiology, pathology, and pharmacology to reinforce your understanding and test readiness.80
- 9.1U01.10.001 Tongue development
- 9.2U01.10.002 Normal gastrointestinal embryology
- 9.3U01.10.003 Ventral wall defects
- 9.4U01.10.004 Congenital umbilical hernia
- 9.5U1.10.005 Tracheoesophageal anomalies
- 9.6U1.10.006 Hypertrophic pyloric stenosis
- 9.7U1.10.007 Intestinal atresia
- 9.8U1.10.008 Pancreas and spleen embryology
- 9.9U1.10.009 Retroperitoneal structures
- 9.10U1.10.010 Important gastrointestinal ligaments
- 9.11U1.10.011 Digestive tract anatomy
- 9.12U1.10.012 Digestive tract histology
- 9.13U1.10.013 Abdominal aorta and branches
- 9.14U1.10.014 Nutcracker syndrome
- 9.15U1.10.015 Superior mesenteric artery syndrome
- 9.16U1.10.016 Gastrointestinal blood supply and innervation
- 9.17U1.10.017 Celiac trunk
- 9.18U1.10.018 Portosystemic anastomoses
- 9.19U1.10.019 Pectinate line
- 9.20U1.10.020 Liver tissue architecture
- 9.21U1.10.021 Biliary structures
- 9.22U1.10.022 Femoral region
- 9.23U1.10.023 Inguinal canal
- 9.24U1.10.024 Myopectineal orifice
- 9.25U1.10.025 Hernias
- 9.26U1.10.026 Gastrointestinal regulatory substances
- 9.27U1.10.027 Gastrointestinal secretory products
- 9.28U1.10.028 Locations of gastrointestinal secretory cells
- 9.29U1.10.029 Pancreatic secretions
- 9.30U1.10.030 Carbohydrate absorption
- 9.31U1.10.031 Vitamin and mineral absorption
- 9.32U1.10.032 Peyer patches
- 9.33U1.10.033 Bile
- 9.34U1.10.034 Bilirubin
- 9.35U1.10.035 Oral pathologies
- 9.36U1.10.036 Achalasia
- 9.37U1.10.037 Other esophageal pathologies
- 9.38U1.10.038 Barrett esophagus
- 9.39U1.10.039 Esophageal cancer
- 9.40U1.10.040 Gastritis
- 9.41U1.10.041 Ménétrier disease
- 9.42U1.10.042 Gastric cancer
- 9.43U1.10.043 Peptic ulcer disease
- 9.44U1.10.044 Ulcer complications
- 9.45U1.10.045 Acute gastrointestinal bleeding
- 9.46U1.10.046 Malabsorption syndromes
- 9.47U1.10.047 Inflammatory bowel diseases
- 9.48U1.10.048 Microscopic colitis
- 9.49U1.10.049 Irritable bowel syndrome
- 9.50U1.10.050 Diverticula of the GI tract
- 9.51U1.10.051 Zenker diverticulum
- 9.52U1.10.052 Meckel diverticulum
- 9.53U1.10.053 Hirschsprung disease
- 9.54U1.10.054 Malrotation
- 9.55U1.10.055 Intussusception
- 9.56U1.10.056 Volvulus
- 9.57U1.10.057 Short bowel syndrome
- 9.58U1.10.058 Other intestinal disorders
- 9.59U1.10.059 Colonic polyp
- 9.60U1.10.060 Polyposis syndromes
- 9.61U1.10.061 Lynch syndrome
- 9.62U1.10.062 Colorectal cancer
- 9.63U1.10.063 Molecular pathogenesis of colorectal cancer
- 9.64U1.10.064 Cirrhosis and portal hypertension
- 9.65U1.10.065 Budd-Chiari syndrome
- 9.66U1.10.066 Spontaneous bacterial peritonitis
- 9.67U1.10.067 Serum markers of liver pathology
- 9.68U1.10.068 Reye syndrome
- 9.69U1.10.069 Alcoholic liver disease
- 9.70U1.10.070 Steatotic liver disease
- 9.71U1.10.071 Autoimmune hepatitis
- 9.72U1.10.072 Hepatic encephalopathy
- 9.73U1.10.073 Liver tumors
- 9.74U1.10.074 ɑ1-antitrypsin deficiency
- 9.75U1.10.075 Jaundice
- 9.76U1.10.076 Benign neonatal hyperbilirubinemia
- 9.77U1.10.077 Biliary atresia
- 9.78U1.10.078 Hereditary hyperbilirubinemias
- 9.79U1.10.079 Wilson disease
- 9.80U1.10.080 Hemochromatosis
- U01.10 Hematology and OncologyThis review covers essential Hematology and Oncology topics for the USMLE Step 1, including hematopoiesis, coagulation, anemias, leukemias, lymphomas, and neoplastic syndromes.149
- 10.1Macrophages
- 10.2Eosinophils
- 10.3Basophils
- 10.4Mast cells
- 10.5Dendritic cells
- 10.6Lymphocytes
- 10.7Natural killer cells
- 10.8B cells
- 10.9T cells
- 10.10Plasma cells
- 10.11Hemoglobin electrophoresis
- 10.12Platelet plug formation (Primary hemostasis)
- 10.13Thrombogenesis
- 10.14Coagulation and kinin pathways
- 10.15Vitamin K–dependent coagulation
- 10.16RBC morphology pathologies
- 10.17RBC inclusions
- 10.18Anemias
- 10.19Reticulocyte index
- 10.20Microcytic, hypochromic anemias
- 10.21Iron deficiency
- 10.22α-thalassemia
- 10.23β-thalassemia
- 10.24Lead poisoning
- 10.25Sideroblastic anemia
- 10.26Interpretation of iron studies
- 10.27Macrocytic anemias
- 10.28Megaloblastic anemia
- 10.29Folate deficiency
- 10.30Vitamin B12 (cobalamin) deficiency
- 10.31Orotic aciduria
- 10.32Nonmegaloblastic anemia
- 10.33Normocytic, normochromic anemias
- 10.34Nonhemolytic, normocytic anemias
- 10.35Anemia of chronic disease
- 10.36Aplastic anemia
- 10.37Hereditary spherocytosis
- 10.38G6PD deficiency
- 10.39Pyruvate kinase deficiency
- 10.40Paroxysmal nocturnal hemoglobinuria
- 10.41Sickle cell anemia
- 10.42HbC disease
- 10.43Extrinsic hemolytic anemias
- 10.44Autoimmune hemolytic anemia
- 10.45Microangiopathic hemolytic anemia
- 10.46Macroangiopathic hemolytic anemia
- 10.47Hemolytic anemia due to infection
- 10.48Leukopenias
- 10.49Neutrophil left shift
- 10.50Heme synthesis, porphyrias, and lead poisoning
- 10.51Lead poisoning
- 10.52Acute intermittent porphyria
- 10.53Porphyria cutanea tarda
- 10.54Iron poisoning
- 10.55Coagulation disorders
- 10.56Platelet disorders
- 10.57Bernard-Soulier syndrome
- 10.58Glanzmann thrombasthenia
- 10.59Immune thrombocytopenia
- 10.60Thrombotic microangiopathies
- 10.61Mixed platelet and coagulation disorders
- 10.62Hereditary thrombosis syndromes
- 10.63Antithrombin deficiency
- 10.64Factor V Leiden
- 10.65Protein C or S deficiency
- 10.66Prothrombin gene mutation
- 10.67Blood transfusion therapy
- 10.68Leukemia vs lymphoma
- 10.69Hodgkin vs non‑Hodgkin lymphoma
- 10.70Hodgkin lymphoma
- 10.71Non-Hodgkin lymphoma
- 10.72Burkitt lymphoma
- 10.73Diffuse large B-cell lymphoma
- 10.74Follicular lymphoma
- 10.75Follicular lymphoma
- 10.76Mantle cell lymphoma
- 10.77Marginal zone lymphoma
- 10.78Primary central nervous system lymphoma
- 10.79Adult T-cell lymphoma
- 10.80Mycosis fungoides/ Sézary syndrome
- 10.81Plasma cell dyscrasias
- 10.82Multiple myeloma
- 10.83Waldenstrom macroglobulinemia
- 10.84Monoclonal gammopathy of undetermined significance
- 10.85Myelodysplastic syndromes
- 10.86Leukemias
- 10.87Lymphoid neoplasms Acute lymphoblastic leukemia/lymphoma
- 10.88Chronic lymphocytic leukemia/small lymphocytic lymphoma
- 10.89Hairy cell leukemia
- 10.90Acute myelogenous leukemia
- 10.91Chronic myelogenous leukemia
- 10.92Chronic myeloproliferative disorders
- 10.93Polycythemia vera
- 10.94Essential thrombocythemia
- 10.95Myelofibrosis
- 10.96Polycythemia
- 10.97Chromosomal translocations
- 10.98Langerhans cell histiocytosis
- 10.99Tumor lysis syndrome
- 10.100Hemophagocytic lymphohistiocytosis
- 10.101Direct thrombin inhibitors
- 10.102Heparin
- 10.103Warfarin
- 10.104Heparin vs warfarin
- 10.105Direct factor Xa inhibitor
- 10.106Thrombolytics
- 10.107ADP receptor inhibitors
- 10.108Glycoprotein IIb/IIIa inhibitors
- 10.109Glycoprotein IIb/IIIa inhibitors
- 10.110Cancer therapy—targets
- 10.111Antitumor antibiotics
- 10.112Antimetabolites
- 10.113Azathioprine, 6-mercaptopurine
- 10.114Cladribine
- 10.115Cytarabine (arabinofuranosyl cytidine
- 10.1165-fluorouracil
- 10.117Methotrexate
- 10.118Alkylating agents
- 10.119Busulfan
- 10.120Cyclophosphamide, ifosfamide
- 10.121Nitrosoureas (eg, carmustine, lomustine)
- 10.122Procarbazine
- 10.123Microtubule inhibitors
- 10.124Paclitaxel, other taxanes
- 10.125Vincristine, vinblastine
- 10.126Cisplatin, carboplatin, oxaliplatin
- 10.127Etoposide, teniposide
- 10.128Irinotecan, topotecan
- 10.129Hydroxyurea
- 10.130Bevacizumab
- 10.131Erlotinib
- 10.132Cetuximab, panitumumab
- 10.133Imatinib, dasatinib, nilotinib
- 10.134Rituximab
- 10.135Bortezomib, carfilzomib
- 10.136Tamoxifen, raloxifene
- 10.137Trastuzumab
- 10.138Dabrafenib, vemurafenib
- 10.139Rasburicase
- 10.140Key chemotoxicities
- 10.141U01.10.001 Fetal Erythropoiesis
- 10.142U01.10.002 Blood groups
- 10.143U01.10.003 Hemolytic Disease of the Fetus and Newborn
- 10.144U01.10.004 Hematopoiesis
- 10.145U01.10.005 Neutrophils
- 10.146U01.10.006 Erythrocytes
- 10.147U01.10.007 Thrombocytes (platelets)
- 10.148U01.10.008 Monocytes
- 10.149U01.10.009 Macrophages
- U01.11 Musculoskeletal, Skin, and Connective TissueReview essential topics for the USMLE Step 1 Musculoskeletal, Skin, and Connective Tissue systems, covering anatomy, physiology, pathology, and pharmacology fundamentals critical for exam success.178
- 11.1Rotator cuff muscles
- 11.2Arm abduction
- 11.3Upper extremity nerves
- 11.4Axillary (C5-C6)
- 11.5Musculocutaneous (C5-C7)
- 11.6Radial (C5-T1)
- 11.7Median (C5-T1)
- 11.8Ulnar (C8-T1)
- 11.9Recurrent branch of median nerve (C5-T1)
- 11.10Brachial plexus lesions
- 11.11Erb palsy (“waiter’s tip”)
- 11.12Klumpke palsy
- 11.13Thoracic outlet syndrome
- 11.14Winged scapula
- 11.15Wrist region
- 11.16Hand muscle
- 11.17Distortions of the hand
- 11.18Actions of hip muscles
- 11.19Lower extremity nerves
- 11.20Iliohypogastric (T12-L1)
- 11.21Genitofemoral nerve (L1-L2)
- 11.22Lateral femoral cutaneous (L2-L3)
- 11.23Obturator (L2-L4)
- 11.24Femoral (L2-L4)
- 11.25Sciatic (L4-S3)
- 11.26Common (fibular) peroneal (L4-S2)
- 11.27Tibial (L4-S3)
- 11.28Inferior gluteal (L5-S2)
- 11.29Superior gluteal (L4‑S1)
- 11.30Pudendal (S2-S4)
- 11.31Knee exam
- 11.32Anterior drawer sign
- 11.33Posterior drawer sign
- 11.34Abnormal passive abduction
- 11.35Abnormal passive adduction
- 11.36McMurray test
- 11.37Ankle sprains
- 11.38Signs of lumbosacral radiculopathy
- 11.39Neurovascular pairing
- 11.40Motoneuron action potential to muscle contraction
- 11.41Types of muscle fibers
- 11.42Vascular smooth muscle contraction and relaxation
- 11.43Muscle proprioceptors
- 11.44Bone formation
- 11.45Cell biology of bone
- 11.46Overuse injuries of the elbow
- 11.47Wrist and hand injuries
- 11.48Metacarpal neck fracture
- 11.49Carpal tunnel syndrome
- 11.50Guyon canal syndrome
- 11.51Clavicle fractures
- 11.52“Unhappy triad”
- 11.53Prepatellar bursitis
- 11.54Baker cyst
- 11.55De Quervain tenosynovitis
- 11.56Ganglion cyst
- 11.57Iliotibial band syndrome
- 11.58Limb compartment syndrome
- 11.59Medial tibial stress
- 11.60Plantar fasciitis
- 11.61Developmental dysplasia of the hip
- 11.62Legg-Calvé-Perthes disease
- 11.63Osgood-Schlatter disease
- 11.64Patellofemoral syndrome
- 11.65Radial head subluxation
- 11.66Slipped capital femoral epiphysis
- 11.67Greenstick fracture
- 11.68Achondroplasia
- 11.69Torus (buckle) fracture
- 11.70Osteoporosis
- 11.71Osteomalacia/rickets
- 11.72Osteitis deformans
- 11.73Avascular necrosis of bone
- 11.74Lab values in bone disorders
- 11.75Primary bone tumors
- 11.76Osteochondroma
- 11.77Osteoblastoma
- 11.78Osteoma
- 11.79Osteoid osteoma
- 11.80Giant cell tumor
- 11.81Chondroma
- 11.82Chondrosarcoma
- 11.83Osteosarcoma (osteogenic sarcoma)
- 11.84Ewing sarcoma
- 11.85Osteoarthritis vs rheumatoid arthritis
- 11.86Gout
- 11.87Calcium pyrophosphate deposition disease
- 11.88Systemic juvenile idiopathic arthritis
- 11.89Sjögren syndrome
- 11.90Septic arthritis
- 11.91Seronegative spondyloarthritis
- 11.92Psoriatic arthritis
- 11.93Ankylosing spondylitis
- 11.94Inflammatory bowel disease
- 11.95Reactive arthritis
- 11.96Systemic lupus erythematosus
- 11.97Mixed connective tissue disease
- 11.98Antiphospholipid syndrome
- 11.99Polymyalgia rheumatica
- 11.100Fibromyalgia
- 11.101Polymyositis
- 11.102Dermatomyositis
- 11.103Myasthenia gravis
- 11.104Lambert-Eaton myasthenic syndrome
- 11.105Raynaud phenomenon
- 11.106Scleroderma
- 11.107Skin layers
- 11.108Epithelial cell junctions
- 11.109Dermatologic macroscopic terms
- 11.110Dermatologic microscopic terms
- 11.111Albinism
- 11.112Melasma (chloasma)
- 11.113Vitiligo
- 11.114Seborrheic dermatitis
- 11.115Acne
- 11.116Atopic dermatitis (eczema)
- 11.117Allergic contact dermatitis
- 11.118Melanocytic nevus
- 11.119Pseudofolliculitis barbae
- 11.120Psoriasis
- 11.121Rosacea
- 11.122Seborrheic keratosis
- 11.123Verrucae
- 11.124Urticaria
- 11.125Angiosarcoma
- 11.126Bacillary angiomatosis
- 11.127Cherry hemangioma
- 11.128Glomus tumor
- 11.129Kaposi sarcoma
- 11.130Pyogenic granuloma
- 11.131Strawberry hemangioma
- 11.132Impetigo
- 11.133Erysipelas
- 11.134Cellulitis
- 11.135Abscess
- 11.136Necrotizing fasciitis
- 11.137Staphylococcal scalded skin syndrome
- 11.138Herpes
- 11.139Molluscum contagiosum
- 11.140Varicella zoster virus
- 11.141Hairy leukoplakia
- 11.142Pemphigus vulgaris
- 11.143Bullous pemphigoid
- 11.144Dermatitis herpetiformis
- 11.145Erythema multiforme
- 11.146Stevens-Johnson syndrome
- 11.147Acanthosis nigricans
- 11.148Actinic keratosis
- 11.149Erythema nodosum
- 11.150Lichen Planus
- 11.151Pityriasis rosea
- 11.152Sunburn
- 11.153Rule of 9’s
- 11.154Burn classification
- 11.155Skin cancer
- 11.156Basal cell carcinoma
- 11.157Keratoacanthoma
- 11.158Melanoma
- 11.159Squamous cell carcinoma
- 11.160Arachidonic acid pathways
- 11.161Acetaminophen
- 11.162Aspirin
- 11.163Celecoxib
- 11.164Nonsteroidal anti-inflammatory drugs
- 11.165Leflunomide
- 11.166Bisphosphonates
- 11.167Teriparatide
- 11.168Gout drugs
- 11.169Probenecid
- 11.170Allopurinol
- 11.171Pegloticase
- 11.172Febuxostat
- 11.173NSAIDs
- 11.174Glucocorticoids
- 11.175Colchicine
- 11.176TNF-α inhibitors
- 11.177Etanercept
- 11.178Infliximab, adalimumab, certolizumab
- U01.12 Neurology and Special SensesMaster the foundational concepts of Neurology and Special Senses with our USMLE Step 1 review, covering essential topics like neuroanatomy, neurophysiology, and sensory pathways.140
- 12.1U01.12.001 Neural development20 Minutes
- 12.2U01.12.002 Regional specification of developing brain
- 12.3U01.12.003 Central and peripheral nervous systems origins
- 12.4U01.12.004 Neural tube defects
- 12.5U01.12.005 Brain malformations
- 12.6U01.12.006 Posterior fossa malformations
- 12.7U01.12.007 Syringomyelia
- 12.8U01.12.008 Cells of the nervous system
- 12.9U01.12.009 Neuron action potential
- 12.10U01.12.010 Astrocytes
- 12.11U01.12.011 Sensory receptors
- 12.12U01.12.012 Peripheral nerve
- 12.13U01.12.013 Neuronal response to axonal injury
- 12.14U01.12.014 Neurotransmitter changes with disease20 Minutes
- 12.15U01.12.015 Meninges
- 12.16U01.12.016 Blood-brain barrier
- 12.17U01.12.017 Vomiting center
- 12.18U01.12.018 Sleep physiology
- 12.19U01.12.019 REM sleep behavior disorder
- 12.20U01.12.020 Factors affecting sleep architecture
- 12.21U01.12.021 Hypothalamus15 Minutes
- 12.22U01.12.022 Thalamus
- 12.23U01.12.023 Limbic system
- 12.24U01.12.024 Dopaminergic pathways
- 12.25U01.12.025 Cerebellum
- 12.26U01.12.026 Basal ganglia
- 12.27U01.12.027 Cerebral cortex regions
- 12.28U01.12.028 Cerebral perfusion
- 12.29U01.12.029 Homunculus
- 12.30U01.12.030 Cerebral arteries—cortical distribution
- 12.31U01.12.031 Circle of Willis
- 12.32U01.12.032 Dural venous sinuses
- 12.33U01.12.033 Ventricular system
- 12.34U01.12.034 Brain stem—ventral view
- 12.35U01.12.035 Brain stem—dorsal view
- 12.36U01.12.036 Brainstem cross sections
- 12.37U01.12.037 Cranial nerve nuclei
- 12.38U01.12.038 Vagal nuclei
- 12.39U01.12.039 Cranial nerve and vessel pathways
- 12.40U01.12.040 Cranial nerves
- 12.41U01.12.041 Cranial nerve reflexes
- 12.42U01.12.042 Mastication muscles
- 12.43U01.12.043 Spinal nerves
- 12.44U01.12.044 Conus medullaris and cauda equina syndrome
- 12.45U01.12.045 Spinal cord—lower extent
- 12.46U01.12.046 Spinal cord and associated tracts
- 12.47U01.12.047 Spinal tract anatomy and functions
- 12.48U01.12.048 Clinical reflexes
- 12.49U01.12.049 Primitive reflexes
- 12.50U01.12.050 Landmark dermatomes
- 12.51U01.12.051 Common brain lesions20 Minutes
- 12.52U01.12.052 Abnormal motor posturing
- 12.53U01.12.053 Ischemic brain disease/stroke
- 12.54U01.12.054 Cerebral edema
- 12.55U01.12.055 Effects of strokes20 Minutes
- 12.56U01.12.056 Neonatal intraventricular hemorrhage
- 12.57U01.12.057 Extracranial injuries
- 12.58U01.12.058 Intracranial hemorrhage
- 12.59U01.12.059 Thalamic pain syndrome
- 12.60U01.12.060 Phantom limb pain
- 12.61U01.12.061 Diffuse axonal injury
- 12.62U01.12.062 Aphasia
- 12.63U01.12.063 Aneurysms
- 12.64U01.12.064 Fever vs heat stroke
- 12.65U01.12.065 Seizures
- 12.66U01.12.066 Headaches
- 12.67U01.12.067 Trigeminal neuralgia
- 12.68U01.12.068 Dyskinesias
- 12.69U01.12.069 Restless legs syndrome20 Minutes
- 12.70U01.12.070 Neurodegenerative disorders
- 12.71U01.12.071 Dementia
- 12.72U01.12.072 Idiopathic intracranial hypertension
- 12.73U01.12.073 Hydrocephalus
- 12.74U01.12.074 Multiple sclerosis
- 12.75U01.12.075 Other demyelinating and dysmyelinating disorders20 Minutes
- 12.76U01.12.076 Neurocutaneous disorders15 Minutes
- 12.77U01.12.077 Adult primary brain tumors25 Minutes
- 12.78U01.12.078 Childhood primary brain tumors20 Minutes
- 12.79U01.12.079 Herniation syndromes
- 12.80U01.12.080 Motor neuron signs
- 12.81U01.12.081 Spinal lesions
- 12.82U01.12.082 Poliomyelitis
- 12.83U01.12.083 Brown-Séquard syndrome
- 12.84U01.12.084 Friedreich ataxia
- 12.85U01.12.085 Cerebral palsy
- 12.86U01.12.086 Common cranial nerve lesions
- 12.87U01.12.087 Facial nerve lesions
- 12.88U01.12.088 Auditory anatomy and physiology
- 12.89U01.12.089 Otitis externa
- 12.90U01.12.090 Otitis media
- 12.91U01.12.091 Common causes of hearing loss
- 12.92U01.12.092 Diagnosing hearing loss
- 12.93U01.12.093 Cholesteatoma
- 12.94U01.12.094 Vertigo
- 12.95U01.12.095 Normal eye anatomy
- 12.96U01.12.096 Conjunctivitis
- 12.97U01.12.097 Refractive errors
- 12.98U01.12.098 Lens disorders
- 12.99U01.12.099 Aqueous humor pathway
- 12.100U01.12.100 Glaucoma
- 12.101U01.12.101 Age-related macular degeneration
- 12.102U01.12.102 Retinal disorders
- 12.103U01.12.102 Papilledema
- 12.104U01.12.104 Leukocoria
- 12.105U01.12.105 Uveitis
- 12.106U01.12.106 Pupillary control
- 12.107U01.12.107 Relative afferent pupillary defect
- 12.108U01.12.108 Horner syndrome
- 12.109U01.12.109 Ocular motility
- 12.110U01.12.110 Strabismus
- 12.111U01.12.111 III, IV, VI palsies
- 12.112U01.12.112 Visual field defects
- 12.113U01.12.113 Cavernous sinus
- 12.114U01.12.114 Internuclear ophthalmoplegia
- 12.115U01.12.115 Eyelid disorders
- 12.116U01.12.116 Epilepsy therapy
- 12.117U01.12.117 Barbiturates
- 12.118U01.12.118 Benzodiazepines
- 12.119U01.12.119 Insomnia therapy
- 12.120U01.12.120 Triptans Sumatriptan
- 12.121U01.12.121 Parkinson disease therapy
- 12.122U01.12.122 Carbidopa/levodopa
- 12.123U01.12.123 Neurodegenerative disease therapy
- 12.124U01.12.124 Local anesthetics
- 12.125U01.12.125 Anesthetics—general principles
- 12.126U01.12.126 Neuromuscular blocking drugs
- 12.127U01.12.127 Malignant hyperthermia
- 12.128U01.12.128 Skeletal muscle relaxants
- 12.129U01.12.129 Opioid analgesics
- 12.130U01.12.130 Tramadol
- 12.131U01.12.131 Butorphanol, nalbuphine
- 12.132U01.12.132 Capsaicin
- 12.133U01.12.133 Glaucoma therapy
- 12.134U01.12.001 Neural development
- 12.135U01.12.002 Regional specification of developing brain
- 12.136U01.12.003 Central and peripheral nervous systems origins
- 12.137U01.12.004 Neural tube defects
- 12.138U01.12.005 Brain malformations
- 12.139U01.12.006 Posterior fossa malformations
- 12.140U01.12.007 Syringomyelia
- U01.13 PsychiatryPsychiatry for the USMLE Step 1 focuses on understanding the pathophysiology, diagnosis, and treatment of psychiatric disorders, with an emphasis on key concepts like neurotransmitter imbalances, mental health disorders, and pharmacology.79
- 13.1Major depressive disorder
- 13.2Depression with atypical features
- 13.3Peripartum mood disturbances
- 13.4Electroconvulsive therapy
- 13.5Risk factors for suicide completion
- 13.6Anxiety disorders
- 13.7Panic disorder
- 13.8Phobias
- 13.9Generalized anxiety disorder
- 13.10Obsessive-compulsive disorders
- 13.11Trichotillomania
- 13.12Trauma and stress-related disorders
- 13.13Adjustment disorder
- 13.14Post-traumatic stress disorder
- 13.15Diagnostic criteria by symptom duration20 Minutes
- 13.16Personality
- 13.17Malingering
- 13.18Factitious disorders
- 13.19Somatic symptom and related disorders
- 13.20Eating disorders
- 13.21Gender dysphoria
- 13.22Sexual dysfunction
- 13.23Sleep terror disorder
- 13.24Narcolepsy
- 13.25Enuresis
- 13.26Substance use disorder
- 13.27Stages of change in overcoming addiction
- 13.28Psychiatric emergencies
- 13.29Serotonin syndrome
- 13.30Hypertensive crisis
- 13.31Neuroleptic malignant syndrome
- 13.32Delirium tremens
- 13.33Acute dystonia
- 13.34Lithium toxicity
- 13.35Tricyclic antidepressant toxicity
- 13.36Psychoactive drug intoxication and withdrawal
- 13.37Depressants
- 13.38Stimulants
- 13.39Hallucinogens
- 13.40Alcohol use disorder
- 13.41Psychotherapy
- 13.42Preferred medications for selected psychiatric condition20 Minutes
- 13.43Central nervous system stimulants
- 13.44Typical antipsychotics
- 13.45Atypical antipsychotics
- 13.46Lithium
- 13.47Buspirone
- 13.48Antidepressants
- 13.49Selective serotonin reuptake inhibitors
- 13.50Serotoninnorepinephrine reuptake inhibitors
- 13.51Tricyclic antidepressants
- 13.52Monoamine oxidase inhibitors
- 13.53Atypical antidepressants
- 13.54Opioid detoxification and relapse prevention
- 13.55U01.13.001 Classical conditioning
- 13.56U01.13.002 Operant conditioning
- 13.57U01.13.003 Transference and countertransference
- 13.58U01.13.004 Ego defenses
- 13.59U01.13.005 Grief
- 13.60U01.13.006 Normal infant and child development
- 13.61U01.13.007 Child abuse
- 13.62U01.13.008 Vulnerable child syndrome
- 13.63U01.13.009 Childhood and early-onset disorders
- 13.64U01.13.010 Orientation
- 13.65U01.13.011 Amnesias
- 13.66U01.13.012 Dissociative disorders
- 13.67U01.13.013 Delirium
- 13.68U01.13.014 Psycosis
- 13.69U01.13.015 Mood disorders
- 13.70U01.13.016 Schizophrenia spectrum disorders
- 13.71U01.13.016 Manic episode
- 13.72U01.13.018 Hypomanic episode
- 13.73U01.13.019 Bipolar disorder
- 13.74U01.13.020 Major depressive disorder
- 13.75U01.13.021
- 13.76U01.13.022
- 13.77U01.13.023
- 13.78U01.13.024
- 13.79U01.13.025
- U01.14 Renal SystemThe Renal System review for USMLE Step 1 covers key concepts including renal physiology, nephron function, acid-base balance, electrolyte regulation, and renal pathology, crucial for understanding both normal and abnormal kidney functions.83
- 14.1U01.14.001 Kidney embryology
- 14.2Potter sequence (syndrome)
- 14.3Horseshoe kidney
- 14.4Congenital solitary functioning kidney
- 14.5Duplex collecting system
- 14.6Posterior urethral valves
- 14.7Kidney anatomy and glomerular structure
- 14.8Course of ureters
- 14.9Fluid compartments
- 14.10Glomerular filtration barrier
- 14.11Renal clearance
- 14.12Glomerular filtration rate
- 14.13Effective renal plasma flow
- 14.14Filtration
- 14.15Changes in glomerular dynamics
- 14.16Calculation of reabsorption and secretion rate
- 14.17Glucose clearance
- 14.18Nephron transport physiology
- 14.19Renal tubular defects
- 14.20Fanconi syndrome
- 14.21Bartter syndrome
- 14.22Gitelman syndrome
- 14.23Liddle syndrome
- 14.24Syndrome of Apparent Mineralocorticoid Excess
- 14.25Relative concentrations along proximal convoluted tubules
- 14.26Renin-angiotensin-aldosterone system
- 14.27Juxtaglomerular apparatus
- 14.28Kidney endocrine functions
- 14.29Hormones acting on kidney
- 14.30Potassium shifts
- 14.31Electrolyte disturbance
- 14.32Features of renal disorder20 Minutes
- 14.33Acid-base physiology
- 14.34Acidosis and alkalosis
- 14.35Renal tubular acidosis
- 14.36Casts in urine
- 14.37Nomenclature of glomerular disorders
- 14.38Glomerular diseases
- 14.39Nephritic syndrome
- 14.40Nephrotic syndrome
- 14.41Nephritic-nephrotic syndrome
- 14.42Acute poststreptococcal glomerulonephritis
- 14.43Rapidly progressive (crescentic) glomerulonephritis
- 14.44Diffuse proliferative glomerulonephritis
- 14.45IgA nephropathy (Berger disease)
- 14.46Alport syndrome
- 14.47Membranoproliferative glomerulonephritis
- 14.48Minimal change disease
- 14.49Focal segmental glomerulosclerosis
- 14.50Membranous nephropathy
- 14.51Amyloidosis
- 14.52Diabetic glomerulonephropathy
- 14.53Kidney stones20 Minutes
- 14.54Hydronephrosis
- 14.55Urinary incontinence
- 14.56Acute cystitis
- 14.57Pyelonephritis
- 14.58Acute kidney injury
- 14.59Acute interstitial nephritis
- 14.60Acute tubular necrosis
- 14.61Diffuse cortical necrosis
- 14.62Renal papillary necrosis
- 14.63Consequences of renal failure
- 14.64Renal osteodystrophy
- 14.65Renal cyst disorders20 Minutes
- 14.66Renovascular disease
- 14.67Renal cell carcinoma
- 14.68Renal oncocytoma
- 14.69Nephroblastoma
- 14.70Urothelial carcinoma of the bladder
- 14.71Squamous cell carcinoma of the bladder
- 14.72Diuretics site of action
- 14.73Mannitol
- 14.74Acetazolamide
- 14.75Loop diuretics
- 14.76Thiazide diuretics
- 14.77Potassium-sparing diuretics
- 14.78Diuretics: electrolyte changes
- 14.79Angiotensinconverting enzyme inhibitors
- 14.80Angiotensin II receptor blockers
- 14.81Aliskiren
- 14.82U01.14.001 Kidney embryology
- 14.83U01.14.002 Potter sequence (syndrome)
- U01.15 Reproductive SystemThe USMLE Step 1 Reproductive System review covers key concepts in human reproduction, including anatomy, physiology, endocrinology, and common pathologies affecting both male and female reproductive health.124
- 15.1Important genes of embryogenesis25 Minutes
- 15.2Early fetal development30 Minutes
- 15.3Embryologic derivatives40 Minutes
- 15.4Types of errors in morphogenesis20 Minutes
- 15.5Teratogens
- 15.6Fetal alcohol syndrome10 Minutes
- 15.7Neonatal abstinence syndrome15 Minutes
- 15.8Twinning
- 15.9Placenta15 Minutes
- 15.10Umbilical cord
- 15.11Urachus15 Minutes
- 15.12Vitelline duct15 Minutes
- 15.13Aortic arch derivatives25 Minutes
- 15.14Pharyngeal apparatus15 Minutes
- 15.15Pharyngeal cleft derivatives15 Minutes
- 15.16Pharyngeal arch derivatives25 Minutes
- 15.17Pharyngeal pouch derivatives20 Minutes
- 15.18Cleft lip and cleft palate15 Minutes
- 15.19Genital embryology20 Minutes
- 15.20Sexual differentiation20 Minutes
- 15.21Uterine (Müllerian duct) anomalies
- 15.22Male/female genital homologs
- 15.23Congenital penile abnormalities
- 15.24Descent of testes and ovaries
- 15.25Gonadal drainage
- 15.26Female reproductive anatomy
- 15.27Adnexal torsion
- 15.28Female reproductive epithelial histology
- 15.29Male reproductive anatomy
- 15.30Urethral injury
- 15.31Autonomic innervation of male sexual response
- 15.32Seminiferous tubules
- 15.33Spermatogenesis
- 15.34Estrogen
- 15.35Progesterone
- 15.36Oogenesis
- 15.37Ovulation
- 15.38Menstrual cycle
- 15.39Abnormal uterine bleeding
- 15.40Pregnancy
- 15.41Human chorionic gonadotropin
- 15.42Human placental lactogen
- 15.43Apgar score
- 15.44Infant and child development
- 15.45Low birth weight
- 15.46Lactation
- 15.47Menopause
- 15.48Androgens
- 15.49Tanner stages of sexual development
- 15.50Tanner stages of sexual development
- 15.51Precocious puberty
- 15.52Sex chromosome disorder
- 15.53Diagnosing disorders of sex hormones
- 15.54Other disorders of sex development
- 15.55Placental aromatase deficiency
- 15.56Androgen insensitivity syndrome
- 15.575α-reductase deficiency
- 15.58Kallmann syndrome
- 15.59Abruptio placentae
- 15.60Morbidly adherent placenta
- 15.61Placenta previa
- 15.62Vasa previa
- 15.63Postpartum hemorrhage
- 15.64Ectopic pregnancy
- 15.65Amniotic fluid abnormalities
- 15.66Hydatidiform mole
- 15.67Choriocarcinoma
- 15.68Hypertension in pregnancy20 Minutes
- 15.69Gynecologic tumor epidemiology
- 15.70Bartholin cyst and abscess
- 15.71Lichen sclerosus
- 15.72Lichen simplex chronicus
- 15.73Vulvar carcinoma
- 15.74Extramammary Paget disease
- 15.75Imperforate hymen
- 15.76Vaginal tumors
- 15.77Dysplasia and carcinoma in situ
- 15.78Primary ovarian insufficiency
- 15.79Most common causes of anovulation
- 15.80Functional hypothalamic amenorrhea
- 15.81Polycystic ovarian syndrome
- 15.82Primary dysmenorrhea
- 15.83Ovarian cysts
- 15.84Ovarian neoplasms
- 15.85Epithelial tumors
- 15.86Germ cell tumors
- 15.87Sex cord stromal tumors
- 15.88Non-neoplastic uterine conditions
- 15.89Adenomyosis
- 15.90Asherman syndrome
- 15.91Endometrial hyperplasia
- 15.92Endometriosis
- 15.93Endometritis
- 15.94Endometrial carcinoma
- 15.95Leiomyoma (fibroid)
- 15.96Leiomyosarcoma
- 15.97Benign breast diseases
- 15.98Breast cancer20 Minutes
- 15.99Penile pathology25 Minutes
- 15.100Extragonadal germ cell tumors
- 15.101Scrotal masses
- 15.102Testicular tumors35 Minutes
- 15.103Hormone levels in germ cell tumors
- 15.104Epididymitis and orchitis
- 15.105Benign prostatic hyperplasia
- 15.106Benign prostatic hyperplasia
- 15.107Prostatic adenocarcinoma
- 15.108Control of reproductive hormones
- 15.109Goserelin, leuprolide
- 15.110Degarelix
- 15.111Estrogens
- 15.112Selective estrogen receptor modulators
- 15.113Aromatase inhibitors
- 15.114Hormone replacement therapy
- 15.115Progestins
- 15.116Antiprogestins
- 15.117Combined contraception
- 15.118Copper intrauterine device
- 15.119Tocolytics
- 15.120Danazol
- 15.121Testosterone, methyltestosterone
- 15.122Antiandrogens
- 15.123Tamsulosin
- 15.124Minoxidil
- U01.16 Respiratory SystemThe Respiratory System review for the USMLE Step 1 covers key concepts in anatomy, physiology, pathophysiology, and pharmacology essential for understanding respiratory diseases and treatments.61
- 16.1U01.16.001 Lung development25 Minutes
- 16.2U01.16.002 Congenital Lung Malformations20 Minutes
- 16.3U01.16.003 Respiratory Cell Types and Their Functions30 Minutes
- 16.4U01.16.004 Neonatal Respiratory Distress Syndrome (NRDS)35 Minutes
- 16.5U01.16.005 Respiratory tree15 Minutes
- 16.6U01.16.006 Lung Anatomy20 Minutes
- 16.7U01.16.007 Diaphragm structures20 Minutes
- 16.8U01.16.008 Lung volumes35 Minutes
- 16.9U01.16.009 Minute Ventilation15 Minutes
- 16.10U01.16.010 Chest Wall Mechanics30 Minutes
- 16.11U01.16.011 Hemoglobin and Oxygen Transport25 Minutes
- 16.12U01.16.012 Oxygen Content of Blood20 Minutes
- 16.13U01.16.013 Methemoglobin25 Minutes
- 16.14U01.16.014 Oxygen-Hemoglobin Dissociation Curve20 Minutes
- 16.15U01.16.015 Cyanide vs. Carbon Monoxide Poisoning30 Minutes
- 16.16U01.16.016 Pulmonary Circulation20 Minutes
- 16.17U01.16.017 Pulmonary vascular resistance15 Minutes
- 16.18U01.16.018 Alveolar Gas Equation30 Minutes
- 16.19U01.16.019 Oxygen deprivation25 Minutes
- 16.20U01.16.020 Ventilation/perfusion mismatch20 Minutes
- 16.21U01.16.021 Carbon dioxide transport25 Minutes
- 16.22U01.16.022 Response to High Altitude20 Minutes
- 16.23U01.16.023 Response to Exercise20 Minutes
- 16.24U01.16.024 Rhinosinusitis20 Minutes
- 16.25U01.16.025 Epistaxis (Nosebleed)20 Minutes
- 16.26U01.16.026 Head and Neck Cancer20 Minutes
- 16.27U01.16.027 Deep Venous Thrombosis (DVT)25 Minutes
- 16.28U01.16.028 Pulmonary Embolism (PE)25 Minutes
- 16.29U01.16.029 Mediastinal Pathology30 Minutes
- 16.30U01.16.030 Flow-Volume Loops in Lung Disease20 Minutes
- 16.31U01.16.031 Obstructive Lung Diseases60 Minutes
- 16.32U01.16.032 Restrictive Lung Diseases45 Minutes
- 16.33U01.16.033 Sarcoidosis20 Minutes
- 16.34U01.16.034 Inhalation Injury and Sequelae25 Minutes
- 16.35U01.16.035 Pneumoconioses45 Minutes
- 16.36U01.16.036 Mesothelioma20 Minutes
- 16.37U01.16.037 Acute Respiratory Distress Syndrome (ARDS)25 Minutes
- 16.38U01.16.038 Sleep apnea20 Minutes
- 16.39U01.16.039 Pulmonary hypertension35 Minutes
- 16.40U01.16.040 Physical Findings in Select Lung Diseases30 Minutes
- 16.41U01.16.041 Atelectasis20 Minutes
- 16.42U01.16.042 Pleural effusions25 Minutes
- 16.43U01.16.043 Pneumothorax40 Minutes
- 16.44U01.16.044 Lung cancer60 Minutes
- 16.45U01.16.045 Lung abscess25 Minutes
- 16.46U01.16.046 Superior Vena Cava Syndrome (SVCS)15 Minutes
- 16.47U01.16.047 Histamine-1 (H1) blockers20 Minutes
- 16.48U01.16.048 Guaifenesin15 Minutes
- 16.49U01.16.049 N-Acetylcysteine (NAC)15 Minutes
- 16.50U01.16.050 Dextromethorphan15 Minutes
- 16.51U01.16.051 Pseudoephedrine and Phenylephrine15 Minutes
- 16.52U01.16.052 Pulmonary Hypertension Drugs35 Minutes
- 16.53U01.16.053 β2-agonists35 Minutes
- 16.54U01.16.054 Inhaled corticosteroids (ICS)25 Minutes
- 16.55U01.16.054 Muscarinic antagonists30 Minutes
- 16.56U01.16.055 Antileukotrienes: Montelukast, Zafirlukast, and Zileuton35 Minutes
- 16.57U01.16.056 Anti-IgE Monoclonal Therapy: Omalizumab15 Minutes
- 16.58U01.16.057 Theophylline20 Minutes
- 16.59U01.16.058 Chromones20 Minutes
- 16.60U01.16.059 Anti-IL-5 Monoclonal Therapy30 Minutes
- 16.61U01.16.060 Summary of Anti-Asthma Drugs
- U01.17 Review: Pathophysiology of important diseasesUSMLE Step 1 Rapid Review covers essential topics across multiple disciplines, providing a concise, high-yield overview to reinforce key concepts and optimize your exam preparation.42
- 17.1U01.17.001 Lesch-Nyhan syndrome
- 17.2U01.17.002 Lynch syndrome (HNPCC)
- 17.3U01.17.003 ß – thalassemia
- 17.4U01.17.004 Osteogenesis imperfecta
- 17.5U01.17.005 Ehlers-Danlos syndrome (EDS)
- 17.6U01.17.006 Menkes disease
- 17.7U01.17.007 Marfan syndrome
- 17.8U01.17.008 Prader–Willi syndrome
- 17.9U01.17.009 Angelman syndrome
- 17.10U01.17.010 Cystic Fibrosis
- 17.11U01.17.011 Duchenne Muscular Dystrophy (DMD)
- 17.12U01.17.012 Becker Muscular Dystrophy (BMD)
- 17.13U01.17.013 Myotonic Dystrophy (DM1)
- 17.14U01.17.014 Fragile X Syndrome
- 17.15U01.17.015 Bitot spots (Vitamin A deficiency)
- 17.16U01.17.016 Wernicke encephalopathy
- 17.17U01.17.017 Pellagra (secondary to carcinoid syndrome)
- 17.18U01.17.018 Kwashiorkor
- 17.19U01.17.019 Alcohol-induced metabolic derangements
- 17.20U01.17.020 Aspirin-induced hyperthermia (mitochondrial uncoupling)
- 17.21U01.17.021 Hereditary Fructose Intolerance
- 17.22U01.17.022 Essential Fructosuria
- 17.23U01.17.023 Classic Galactosemia
- 17.24U01.17.024 Galactokinase Deficiency
- 17.25U01.17.025 Diabetic complications from sorbitol pathway
- 17.26U01.17.026 Terminal complement deficiency (C5–C9)
- 17.27U01.17.027 Hereditary Angioedema (HAE)
- 17.28U01.17.028 Paroxysmal Nocturnal Hemoglobinuria (PNH)
- 17.29U01.17.029 Type I Hypersensitivity (IgE-mediated)
- 17.30U01.17.030 Type II Hypersensitivity (Antibody-mediated)
- 17.31U01.17.031 Type III Hypersensitivity (Immune complex-mediated)
- 17.32U01.17.032 Type IV Hypersensitivity (T cell–mediated)
- 17.33U01.17.033 Acute hemolytic transfusion reaction
- 17.34U01.17.034 X-linked (Bruton) Agammaglobulinemia
- 17.35U01.17.035 DiGeorge Syndrome (22q11 Deletion Syndrome)
- 17.36U01.17.036 Hyper-IgM Syndrome (CD40L Defect)
- 17.37U01.17.037 Leukocyte Adhesion Deficiency (Type I)
- 17.38U01.17.038 Chédiak–Higashi Syndrome
- 17.39U01.17.039 Chronic Granulomatous Disease (CGD)
- 17.40U01.17.040 Candida infections — T-cell and granulocyte deficiencies
- 17.41U01.17.041 Type IV hypersensitivity reaction caused by donor T cells attacking host tissues after transplantation
- 17.42U01.17.042 Catalase-positive organisms evade killing in CGD
- U01.18 Review: Classic presentationsUpon completion, the learner will be able to accurately recall and articulate the classic constellation of signs, symptoms, and key distinguishing features for common diseases, aiding rapid clinical recognition.72
- 18.1U01.18.001 Lesch-Nyhan syndrome
- 18.2U01.18.002 Primary Ciliary Dyskinesia (Kartagener syndrome)
- 18.3U01.18.003 Osteogenesis Imperfecta
- 18.4U01.18.004 Ehlers-Danlos Syndrome
- 18.5U01.18.005 Marfan Syndrome
- 18.6U01.18.006 Homocystinuria
- 18.7U01.18.007 McCune-Albright syndrome
- 18.8U01.18.008 Cystic fibrosis
- 18.9U01.18.009 Muscular dystrophy
- 18.10U01.18.010 Duchenne muscular dystrophy: Gower sign
- 18.11U01.18.011 Becker muscular dystrophy
- 18.12U01.18.012 Patau syndrome
- 18.13U01.18.013 Edwards syndrome
- 18.14U01.18.014 Down syndrome
- 18.15U01.18.015 Cri-du-chat syndrome
- 18.16U01.18.016 Wernicke-Korsakoff syndrome
- 18.17U01.18.017 Wet beriberi
- 18.18U01.18.018 Pellagra
- 18.19U01.18.019 Pantothenic acid deficiency
- 18.20U01.18.020 Vitamin B12 deficiency
- 18.21U01.18.021 Scurvy
- 18.22U01.18.022 Vitamin D deficiency
- 18.23U01.18.023 Vitamin K deficiency
- 18.24U01.18.024 Phenylketonuria
- 18.25U01.18.025 Alkaptonuria
- 18.26U01.18.026 Glycogen storage disease (Cori or von Gierke)
- 18.27U01.18.027 McArdle disease
- 18.28U01.18.028 Tay-Sachs / Niemann-Pick disease
- 18.29U01.18.029 Gaucher disease
- 18.30U01.18.030 Familial hypercholesterolemia
- 18.31U01.18.031 Bruton disease
- 18.32U01.18.032 Selective IgA deficiency
- 18.33U01.18.033 Hyper-IgE syndrome
- 18.34U01.18.034 Leukocyte adhesion deficiency type 1
- 18.35U01.18.035 Chronic granulomatous disease
- 18.36U01.18.036 Staphylococcal toxic shock syndrome
- 18.37U01.18.037 Strawberry tongue
- 18.38U01.18.038 Streptococcus gallolyticus endocarditis
- 18.39U01.18.039 Clostridium botulinum infection
- 18.40U01.18.040 Clostridioides difficile infection
- 18.41U01.18.041 Corynebacterium diphtheriae infection
- 18.42U01.18.042 Pott disease
- 18.43U01.18.043 Waterhouse-Friderichsen syndrome
- 18.44U01.18.044 Klebsiella pneumoniae infection
- 18.45U01.18.045 Jarisch-Herxheimer reaction
- 18.46U01.18.046 Erythema migrans (Lyme disease)
- 18.47U01.18.047 Genital ulcers
- 18.48U01.18.048 Condylomata lata
- 18.49U01.18.049 Argyll Robertson pupil
- 18.50U01.18.050 Pasteurella multocida infection
- 18.51U01.18.051 Mycoplasma pneumoniae infection
- 18.52U01.18.052 Rash on palms and soles
- 18.53U01.18.053 Mucormycosis
- 18.54U01.18.054 Congenital toxoplasmosis
- 18.55U01.18.055 Hookworm infection
- 18.56U01.18.056 Erythema infectiosum (Fifth disease)
- 18.57U01.18.057 Measles (Rubeola) virus infection
- 18.58U01.18.058 Aortic stenosis
- 18.59U01.18.059 Aortic regurgitation
- 18.60U01.18.060 Patent ductus arteriosus (PDA)
- 18.61U01.18.061 Angina
- 18.62U01.18.062 Angina vs NSTEMI
- 18.63U01.18.063 Postcardiac injury syndrome
- 18.64U01.18.064 Cardiac tamponade
- 18.65U01.18.065 Osler nodes
- 18.66U01.18.066 Janeway lesions
- 18.67U01.18.067 Splinter hemorrhages
- 18.68U01.18.068 Roth spots
- 18.69U01.18.069 Hereditary hemorrhagic telangiectasia
- 18.70U01.18.070 Polyuria and polydipsia
- 18.71U01.18.071 Sheehan syndrome
- 18.72U01.18.072 Hyperthyroidism
- U01.19 Review: Classic Lab findingsThis review explores classical lab findings, foundational for accurate diagnostics. Master hallmark CBCs, electrolytes, enzymes, and serologies to sharpen clinical acumen, confirming diseases and guiding effective patient care.51
- 19.1U01.19.001 Cystic Fibrosis
- 19.2U01.19.002 Second Trimester Screening
- 19.3U01.19.003 First Trimester Screening
- 19.4U01.19.004 Vitamin B12 Deficiency
- 19.5U01.19.005 Drug-Induced Lupus – Serologic Findings
- 19.6U01.19.006 Thymic Aplasia – Laboratory and Diagnostic Findings
- 19.7U01.19.007 Wiskott-Aldrich Syndrome – Laboratory and Clinical Findings
- 19.8U01.19.008 Chédiak-Higashi Disease – Laboratory and Clinical Findings
- 19.9U01.19.009 Optochin Sensitivity – Streptococcal Identification
- 19.10U01.19.010 Novobiocin Sensitivity – Staphylococcal Identification
- 19.11U01.19.011 Bacitracin Sensitivity – Streptococcal Identification
- 19.12U01.19.012 Actinomyces Infection – Laboratory and Diagnostic Findings
- 19.13U01.19.013 Ghon Complex – Primary Tuberculosis
- 19.14U01.19.014 Thumb Sign – Epiglottitis
- 19.15U01.19.015 Clue Cells – Bacterial Vaginosis
- 19.16U01.19.016 Ring-Enhancing Brain Lesion in AIDS
- 19.17U01.19.017 Chagas Disease – Clinical and Laboratory Findings
- 19.18U01.19.018 Infectious Mononucleosis – Laboratory Findings
- 19.19U01.19.019 Steeple Sign – Croup
- 19.20U01.19.020 Negri Bodies – Rabies Infection
- 19.21U01.19.021 Psammoma Bodies – Histopathologic Finding
- 19.22U01.19.022 Boot-Shaped Heart – Tetralogy of Fallot
- 19.23U01.19.023 Rib Notching – Coarctation of the Aorta
- 19.24U01.19.024 Wolff-Parkinson-White Syndrome – ECG Findings
- 19.25U01.19.025 Electrical Alternans – Cardiac Tamponade
- 19.26U01.19.026 Aschoff Bodies – Rheumatic Fever
- 19.27U01.19.027 Elevated Fibrin Degradation Products (D-dimer) — DVT, DIC
- 19.28U01.19.028 “Orphan Annie” Eyes — Papillary Thyroid Carcinoma
- 19.29U01.19.029 “Brown” Tumor of Bone — Hyperparathyroidism / Osteitis Fibrosa Cystica
- 19.30U01.19.030 Hypertension, Hypokalemia, Metabolic Alkalosis — Primary Hyperaldosteronism (Conn Syndrome)
- 19.31U01.19.031 Mucin-Filled Cell with Peripheral Nucleus — “Signet Ring” Cells (Diffuse Gastric Carcinoma)
- 19.32U01.19.032 Anti-Transglutaminase / Anti-Deamidated Gliadin / Anti-Endomysial Antibodies — Celiac Disease
- 19.33U01.19.033 Narrowing of Bowel Lumen on Small Bowel Follow-Through — “String Sign” (Crohn Disease)
- 19.34U01.19.034 “Lead Pipe” Appearance — Ulcerative Colitis
- 19.35U01.19.035 Thousands of Polyps — Familial Adenomatous Polyposis (FAP)
- 19.36U01.19.036 “Apple Core” Lesion — Colorectal Cancer
- 19.37U01.19.037 “Nutmeg” Liver — Chronic Passive Congestion
- 19.38U01.19.038 Mallory Bodies — Alcoholic Hepatitis
- 19.39U01.19.039 Fatty Change — Fatty Liver Disease
- 19.40U01.19.040 Anti-Smooth Muscle and Anti-LKM1 Antibodies — Autoimmune Hepatitis
- 19.41U01.19.041 Antimitochondrial Antibodies — Primary Biliary Cholangitis
- 19.42U01.19.042 ↓ Serum Ceruloplasmin — Wilson Disease
- 19.43U01.19.043 Migratory Thrombophlebitis — Trousseau Syndrome
- 19.44U01.19.044 Basophilic Stippling — Sideroblastic Anemia and Thalassemias
- 19.45U01.19.045 Howell-Jolly Bodies — Post-Splenectomy / Functional Asplenia
- 19.46U01.19.046 Hypochromic Microcytic Anemia
- 19.47U01.19.047 “Hair on End” Skull — Thalassemia / Sickle Cell Anemia
- 19.48U01.19.048 Hypersegmented Neutrophils — Megaloblastic Anemia
- 19.49U01.19.049 Anti-GpIIb/IIIa Antibodies — Immune Thrombocytopenia
- 19.50U01.19.050 “Starry Sky” — Burkitt Lymphoma
- 19.51U01.19.051 “Punched-Out” Bone Lesions — Multiple Myeloma
- U01.20 Review: Classic associationsThis review focuses on classical key associations—the essential, high-yield connections between diseases, clinical signs, lab findings, and pathogens—to build a foundational framework for rapid diagnosis and clinical problem-solving.30
- 20.1U01.20.001 Mitochondrial Inheritance
- 20.2U01.20.002 Intellectual Disability
- 20.3U01.20.003 Vitamin Deficiency (USA)
- 20.4U01.20.004 Lysosomal Storage Disease
- 20.5U01.20.005 HLA-DR3
- 20.6U01.20.006 HLA-DR4
- 20.7U01.20.007 H Pylori
- 20.8U01.20.008 Opportunistic Respiratory Infection in AIDS
- 20.9U01.20.009 Viral Encephalitis
- 20.10U01.20.010 Viral Infection Secondary to Blood Transfusion
- 20.11U01.20.011 Food Poisoning
- 20.12U01.20.012 Healthcare-Associated Pneumonia
- 20.13U01.20.013 Bacterial Meningitis (0–6 Months Old)
- 20.14U01.20.014 Bacterial Meningitis (>6 Months Old)
- 20.15U01.20.015 Osteomyelitis
- 20.16U01.20.016 Osteomyelitis in Sickle Cell Disease
- 20.17U01.20.017 Osteomyelitis with Injection Drug Use
- 20.18U01.20.018 Bacterial Sexually Transmitted Infection
- 20.19U01.20.019 Pelvic Inflammatory Disease (PID)
- 20.20U01.20.019 Pelvic Inflammatory Disease (PID)
- 20.21U01.20.020 Bone Metastases
- 20.22U01.20.021 Liver Metastases
- 20.23U01.20.022 Brain Metastases
- 20.24U01.20.023 S3 Heart Sound
- 20.25U01.20.024 S4 Heart Sound
- 20.26U01.20.025 Holosystolic Murmur
- 20.27U01.20.026 Ejection Click
- 20.28U01.20.027 Mitral Stenosis
- 20.29U01.20.028 Opening Snap
- 20.30U01.20.029 Heart Murmur, Congenital
- U01.21 Equation reviewThis chapter reviews essential pharmacokinetic and physiologic equations for medical students, reinforcing core concepts, problem-solving skills, and clinical applications necessary for exams and patient care calculations.37
- 21.1U01.21.001 Volume of Distribution (Vd)
- 21.2U01.21.002 Half-life (t½)
- 21.3U01.21.003 Drug Clearance (CL)
- 21.4U01.21.004 Loading Dose (LD)
- 21.5U01.21.005 Maintenance Dose (MD)
- 21.6U01.21.006 Therapeutic Index (TI)
- 21.7U01.21.007 Odds Ratio (OR)
- 21.8U01.21.008 Relative Risk (RR)
- 21.9U01.21.009 Attributable Risk (AR)
- 21.10U01.21.010 Relative Risk Reduction (RRR)
- 21.11U01.21.011 Absolute Risk Reduction (ARR)
- 21.12U01.21.012 Number Needed to Treat (NNT)
- 21.13U01.21.013 Number Needed to Harm (NNH)
- 21.14U01.21.014 Likelihood Ratio Positive (LR⁺)
- 21.15U01.21.015 Likelihood Ratio Negative (LR⁻)
- 21.16U01.21.016 Sensitivity
- 21.17U01.21.017 Specificity
- 21.18U01.21.018 Positive Predictive Value (PPV)
- 21.19U01.21.019 Negative Predictive Value (NPV)
- 21.20U01.21.020 Cardiac Output (CO)
- 21.21U01.21.021 Mean Arterial Pressure (MAP)
- 21.22U01.21.022 Stroke Volume (SV)
- 21.23U01.21.023 Ejection Fraction (EF)
- 21.24U01.21.024 Resistance (R)
- 21.25U01.21.025 Capillary Fluid Exchange (Jv)
- 21.26U01.21.026 Reticulocyte Production Index (RPI)
- 21.27U01.21.027 Renal Clearance (Cx)
- 21.28U01.21.028 Glomerular Filtration Rate (GFR)
- 21.29U01.21.029 Effective Renal Plasma Flow (eRPF)
- 21.30U01.21.030 Filtration Fraction (FF)
- 21.31U01.21.031 Fractional Excretion of Sodium (FeNa⁺)
- 21.32U01.21.032 Henderson–Hasselbalch Equation (for Extracellular pH)
- 21.33U01.21.033 Winter’s Formula
- 21.34U01.21.034 Anion Gap (AG)
- 21.35U01.21.035 Physiologic Dead Space (VD)
- 21.36U01.21.036 Pulmonary Vascular Resistance (PVR)
- 21.37U01.21.037 Alveolar Gas Equation (PAO₂)
- U01.22 Commonly Confused Medications – Sound-Alike DrugsThis lesson explores commonly confused medications, highlighting look-alike and sound-alike drugs, their potential risks, and strategies for accurate identification to ensure patient safety and reduce medication errors in clinical practice.20
- 22.1U01.22.001 Amiloride, Amiodarone, Amlodipine
- 22.2U01.22.002 Benztropine, Bromocriptine
- 22.3U01.22.003 Buspirone, Bupropion
- 22.4U01.22.004 Cimetidine, Cetirizine
- 22.5U01.22.005 Chloramphenicol, Chlordiazepoxide
- 22.6U01.22.006 Chlorpheniramine, Chlorthalidone
- 22.7U01.22.007 Clozapine, Clomipramine
- 22.8U01.22.008 Clomiphene, Clonidine
- 22.9U01.22.009 Doxepin, Doxazosin
- 22.10U01.22.010 Eplerenone, Propafenone
- 22.11U01.22.011 Fluoxetine, Fluphenazine
- 22.12U01.22.012 Mifepristone, Misoprostol
- 22.13U01.22.013 Naloxone, Naltrexone
- 22.14U01.22.014 Nitroprusside, Nitroglycerin
- 22.15U01.22.015 Omeprazole, Ketoconazole
- 22.16U01.22.016 Aripiprazole, Anastrozole
- 22.17U01.22.017 Rifaximin, Rifampin
- 22.18U01.22.018 Sertraline, Selegiline
- 22.19U01.22.019 Trazodone, Tramadol
- 22.20U01.22.020 Varenicline, Venlafaxine
U01.16.044 Lung cancer
Lung cancer is the leading cause of cancer death worldwide. It often presents with various respiratory symptoms and can metastasize to multiple sites.
Presentation
Common clinical features of lung cancer include:
- Cough
- Hemoptysis (coughing up blood)
- Bronchial obstruction
- Wheezing
- Pneumonic “coin” lesion on chest X-ray (CXR) or non-calcified nodule on CT scan
Metastasis
Lung cancer commonly metastasizes to the following sites:
- Liver: Symptoms may include jaundice and hepatomegaly.
- Adrenals
- Bone: Can lead to pathologic fractures.
- Brain
Mnemonic for Sites of Metastasis
“Lung ‘mets’ Love Affective Boneheads and Brainiacs.”
Complications
Lung cancer can lead to various complications summarized by the SPHERE acronym:
- Superior vena cava/thoracic outlet syndromes
- Pancoast tumor
- Horner syndrome
- Endocrine (paraneoplastic) syndromes
- Recurrent laryngeal nerve compression (hoarseness)
- Effusions (pleural or pericardial)
Risk Factors
Key risk factors for lung cancer include:
- Smoking
- Secondhand smoke
- Radon exposure
- Asbestos Exposure
- Family history of lung cancer
Histological Types and Characteristics
| Type | Location | Characteristics | Histology Features |
|---|---|---|---|
| Small Cell Carcinoma | Central | Very aggressive, may produce ACTH (Cushing syndrome), ADH (SIADH), or antibodies | Neoplasm of neuroendocrine Kulchitsky cells; small dark blue cells; Chromogranin A ⊕, neuron-specific enolase ⊕, synaptophysin ⊕. Amplification of myc oncogenes is common. Managed with chemotherapy ± radiation. |
| Adenocarcinoma | Peripheral | Most common primary lung cancer; more common in women, often arises in non-smokers. Activating mutations include KRAS, EGFR, and ALK; associated with hypertrophic osteoarthropathy (clubbing). | The glandular pattern on histology often stains mucin ⊕. Bronchioloalveolar subtype shows hazy infiltrates on CXR; better prognosis. |
| Squamous Cell Carcinoma | Central | Hilar mass arising from bronchus; cavitation; associated with smoking and hypercalcemia (produces PTHrP). | Keratin pearls and intercellular bridges. |
| Large Cell Carcinoma | Peripheral | Highly anaplastic undifferentiated tumor; poor prognosis; less responsive to chemotherapy. | Pleomorphic giant cells. |
| Bronchial Carcinoid Tumor | Central or Peripheral | Excellent prognosis; metastasis rare; symptoms due to mass effect or carcinoid syndrome (flushing, diarrhea, wheezing). | Nests of neuroendocrine cells; Chromogranin A ⊕. |
Points to Remember
- Lung cancer is a leading cause of cancer mortality.
- Symptoms can vary widely and may include cough, hemoptysis, and respiratory obstruction.
- Metastatic spread often occurs to the liver, bone, brain, and adrenals.
- Different types of lung cancer present with distinct histological features and treatment responses.