Curriculum

17 Sections
1548 Lessons
100 Days

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U01.01 Biochemistry
This biochemistry review for USMLE Step 1 covers essential topics including metabolism, enzymology, and molecular biology.
126
U01.02 Immunology
Prepare for USMLE Step 1 Immunology with a comprehensive review covering foundational concepts, immune system mechanisms, and key disorders to solidify your understanding and boost exam readiness.
42
U01.03 Microbiology
Review essential microbiology topics for the USMLE Step 1, covering key pathogens, mechanisms of disease, and antimicrobial principles critical for mastering infectious disease concepts.
172
U01.04 General Pathology
Explore key concepts in general pathology essential for the USMLE Step 1. This review covers fundamental principles, disease mechanisms, and clinical correlations to help you excel in your medical exam.
35
U01.05 Pharmacology
Master key pharmacology concepts for the USMLE Step 1 with a focus on drug mechanisms, therapeutic uses, adverse effects, and interactions essential for high-yield exam performance.
43
U01.06 Public Health Sciences
Review essential Public Health Sciences topics for the USMLE Step 1, covering epidemiology, biostatistics, health policy, and ethics to strengthen your understanding of foundational public health principles.
53
U01.07 Cardiovascular system
Comprehensive review of essential cardiovascular system topics to help you excel in the USMLE Step 1 exam, covering key concepts from anatomy to pathology.
73
U01.08 Endocrine system
Master essential concepts of the endocrine system for USMLE Step 1, covering hormone regulation, feedback mechanisms, and key disorders to boost your exam readiness.
51
U01.09 Gastrointestinal system
Review key topics in the gastrointestinal system for the USMLE Step 1, covering essential concepts in anatomy, physiology, pathology, and pharmacology to reinforce your understanding and test readiness.
131
U01.10 Hematology and Oncology
This review covers essential Hematology and Oncology topics for the USMLE Step 1, including hematopoiesis, coagulation, anemias, leukemias, lymphomas, and neoplastic syndromes.
148
U01.11 Musculoskeletal, Skin, and Connective Tissue
Review essential topics for the USMLE Step 1 Musculoskeletal, Skin, and Connective Tissue systems, covering anatomy, physiology, pathology, and pharmacology fundamentals critical for exam success.
178
U01.12 Neurology and Special Senses
Master the foundational concepts of Neurology and Special Senses with our USMLE Step 1 review, covering essential topics like neuroanatomy, neurophysiology, and sensory pathways.
143
U01.13 Psychiatry
Psychiatry for the USMLE Step 1 focuses on understanding the pathophysiology, diagnosis, and treatment of psychiatric disorders, with an emphasis on key concepts like neurotransmitter imbalances, mental health disorders, and pharmacology.
83
U01.14 Renal System
The Renal System review for USMLE Step 1 covers key concepts including renal physiology, nephron function, acid-base balance, electrolyte regulation, and renal pathology, crucial for understanding both normal and abnormal kidney functions.
81
U01.15 Reproductive System
The USMLE Step 1 Reproductive System review covers key concepts in human reproduction, including anatomy, physiology, endocrinology, and common pathologies affecting both male and female reproductive health.
124
U01.16 Respiratory System
The Respiratory System review for the USMLE Step 1 covers key concepts in anatomy, physiology, pathophysiology, and pharmacology essential for understanding respiratory diseases and treatments.
61
U01.17 Rapid Review
he USMLE Step 1 Rapid Review covers essential topics across multiple disciplines, providing a concise, high-yield overview to reinforce key concepts and optimize your exam preparation.
5

U01.01.057 Genetic disorders by chromosome

Understanding genetic disorders by chromosome is crucial for USMLE Step 1 preparation. Below is a list of major genetic disorders, categorized by the chromosome involved. This guide will help students identify key diseases associated with each chromosome, aiding both recall and clinical understanding.

Chromosome 3

Genetic Disorders:
- Von Hippel-Lindau disease
- Renal cell carcinoma

Chromosome 4

Genetic Disorders:
- Autosomal Dominant Polycystic Kidney Disease (ADPKD) – PKD2
- Achondroplasia
- Huntington disease

Chromosome 5

Genetic Disorders:
- Cri-du-chat syndrome
- Familial adenomatous polyposis

Chromosome 6

Genetic Disorders:
- Hemochromatosis (HFE)

Chromosome 7

Genetic Disorders:
- Williams syndrome
- Cystic fibrosis

Chromosome 9

Genetic Disorders:
- Friedreich ataxia
- Tuberous sclerosis (TSC1)

Chromosome 11

Genetic Disorders:
- Wilms tumor
- β-globin gene defects (e.g., sickle cell disease, β-thalassemia)
- Multiple Endocrine Neoplasia Type 1 (MEN1)

Chromosome 13

Genetic Disorders:
- Patau syndrome
- Wilson disease
- Retinoblastoma (RB1)
- BRCA2

Chromosome 15

Genetic Disorders:
- Prader-Willi syndrome
- Angelman syndrome
- Marfan syndrome

Chromosome 16

Genetic Disorders:
- Autosomal Dominant Polycystic Kidney Disease (ADPKD) – PKD1
- α-globin gene defects (e.g., α-thalassemia)
- Tuberous sclerosis (TSC2)

Chromosome 17

Genetic Disorders:
- Neurofibromatosis type 1
- BRCA1
- TP53

Chromosome 18

Genetic Disorders:
- Edwards syndrome

Chromosome 21

Genetic Disorders:
- Down syndrome

Chromosome 22

Genetic Disorders:
- Neurofibromatosis type 2
- DiGeorge syndrome (22q11)

Chromosome X

Genetic Disorders:
- Fragile X syndrome
- X-linked agammaglobulinemia
- Klinefelter syndrome (XXY)

Points to Remember:

Chromosomes and Disease: Memorize key genetic disorders associated with each chromosome.
Autosomal vs X-linked: Distinguish between autosomal dominant and recessive disorders and X-linked conditions.
Clinical Application: Be able to recognize clinical features of these diseases (e.g., Marfan syndrome, neurofibromatosis, cystic fibrosis).
Chromosomal Syndromes: Understand which chromosomal deletions or duplications lead to specific syndromes (e.g., Cri-du-chat, Prader-Willi, Angelman).

Table: Genetic Disorders by Chromosome

Chromosome	Genetic Disorder Examples
3	Von Hippel-Lindau disease, Renal cell carcinoma
4	ADPKD (PKD2), Achondroplasia, Huntington disease
5	Cri-du-chat syndrome, Familial adenomatous polyposis
6	Hemochromatosis (HFE)
7	Williams syndrome, Cystic fibrosis
9	Friedreich ataxia, Tuberous sclerosis (TSC1)
11	Wilms tumor, β-globin gene defects (e.g., sickle cell disease), MEN1
13	Patau syndrome, Wilson disease, Retinoblastoma (RB1), BRCA2
15	Prader-Willi syndrome, Angelman syndrome, Marfan syndrome
16	ADPKD (PKD1), α-globin gene defects, Tuberous sclerosis (TSC2)
17	Neurofibromatosis type 1, BRCA1, TP53
18	Edwards syndrome
21	Down syndrome
22	Neurofibromatosis type 2, DiGeorge syndrome (22q11)
X	Fragile X syndrome, X-linked agammaglobulinemia, Klinefelter syndrome (XXY)

This guide will assist you in efficiently identifying key disorders related to each chromosome and enhance your recall for USMLE Step 1.

USMLE Step 1 Review Series