Key Rate-Limiting Enzymes
| Metabolic Pathway | Rate-Limiting Enzyme |
|---|---|
| Glycolysis | Phosphofructokinase-1 (PFK-1) |
| Gluconeogenesis | Fructose-1,6-bisphosphatase |
| TCA Cycle | Isocitrate dehydrogenase |
| Glycogenesis | Glycogen synthase |
| Glycogenolysis | Glycogen phosphorylase |
| HMP Shunt | Glucose-6-phosphate dehydrogenase (G6PD) |
| Cholesterol Synthesis | HMG-CoA reductase |
High-Yield Clinical Note:
Rate-limiting enzymes serve as the metabolic “bottlenecks” and are the primary targets for hormonal and allosteric control, making them critical nodes for drug intervention (e.g., statins inhibiting HMG-CoA reductase).