Molluscum Contagiosum
A common self-limiting viral infection of the skin caused by a Poxvirus. It is characterized by discrete, dome-shaped papules.
Key Clinical Features
- Appearance: Firm, smooth, pearly, dome-shaped papules with a characteristic central umbilication.
- Transmission: Direct skin-to-skin contact, fomites (towels/sponges), or autoinoculation (Koebner phenomenon) via scratching.
- Distribution: Can occur anywhere, but is commonly found in skin folds (axillae, groin) in children, or as an STI in adults.
Diagnostic & Management Pearls
| Aspect | Details |
|---|---|
| Histology | Henderson-Patterson bodies (large, eosinophilic, intracytoplasmic viral inclusions). |
| Treatment | Often resolves spontaneously; destructive methods (curettage, cryotherapy, podophyllotoxin) for refractory cases. |
High-Yield Exam Pearl:
- Immunocompromised: In patients with HIV/AIDS, Molluscum can present with massive, giant, or widespread lesions. Always test for HIV if an adult presents with widespread, refractory molluscum on the face.
- Differential: Can be confused with *cryptococcosis* in HIV patients, though cryptococcal lesions are typically more ulcerated or papulopustular.