M01.03.001 Anatomy of the Axilla

Learning Objectives

Understand the anatomy of the axilla, including its borders, contents, passageways, and clinical significance, to identify its role as a major conduit for neurovascular and muscular structures of the upper limb.


Introduction to the Axilla

The axilla (armpit) is a pyramidal-shaped space situated beneath the glenohumeral joint. It acts as the gateway between the neck/thorax and the upper limb.


1. Structure and Borders

The axilla is defined by six boundaries. Understanding these is essential for surgical oncology and regional anesthesia.

Border Anatomical Boundaries
Apex (Inlet) Lateral border of 1st rib, superior scapula, and posterior clavicle.
Anterior Wall Pectoralis major, Pectoralis minor, and Subclavius.
Posterior Wall Subscapularis, Teres major, and Latissimus dorsi.
Medial Wall Serratus anterior and the upper ribs.
Lateral Wall Intertubercular (bicipital) groove of the humerus.
Base (Floor) Axillary fascia and skin of the armpit.

2. Contents of the Axilla

The axilla contains vital neurovascular structures embedded in axillary fat.

Structure Key Clinical Feature
Axillary Artery Divided into 3 parts by the pectoralis minor muscle.
Axillary Vein Located medial to the artery; receives the cephalic and basilic veins.
Brachial Plexus Cords and terminal branches (e.g., Median, Ulnar, Radial nerves).
Lymph Nodes Arranged in 5 groups; primary drainage for 75% of breast tissue.

3. Passageways (Exits)

Structures leave the axilla via specific anatomical “doorways” to reach the posterior shoulder or anterior chest.

Passageway Transmitted Structures
Quadrangular Space Axillary nerve and Posterior circumflex humeral artery.
Clavipectoral Triangle Cephalic vein, Thoracoacromial artery, Lateral pectoral nerve.

4. Clinical Relevance

High-Yield Clinical Pearls:

  • Thoracic Outlet Syndrome (TOS): Compression at the Apex. Can be caused by a cervical rib or Pancoast tumor, leading to wasting of intrinsic hand muscles (T1).
  • Winged Scapula: Damage to the Long Thoracic Nerve (C5-C7) during axillary clearance. This paralyzes the Serratus Anterior.
  • Breast Cancer: Axillary lymph nodes are the first site of metastasis for most breast cancers.

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