Competitive Inhibition: Kinetic Impact
| Parameter | Change in Competitive Inhibition |
|---|---|
| Vmax | Unchanged (Can be overcome by high substrate concentrations). |
| Km | Increases (Apparent affinity decreases; more substrate is required). |
High-Yield Core Realities:
- Binding Mechanism: Inhibitor mimics the substrate and binds to the active site.
- Lineweaver-Burk Plot: Y-intercept (1/Vmax) is unchanged; X-intercept (-1/Km) moves closer to zero.
- Clinical Examples: Statins (inhibiting HMG-CoA reductase), Fomepizole (inhibiting alcohol dehydrogenase).