U01.16.046 Superior Vena Cava Syndrome (SVCS)

Superior Vena Cava Syndrome (SVCS) is a serious medical condition resulting from the obstruction of the superior vena cava (SVC), a major vein responsible for returning blood from the upper body to the heart. This obstruction leads to impaired blood drainage from the head, neck, and upper extremities.

Causes

Malignancy: Tumors such as a mediastinal mass or Pancoast tumor.
Thrombosis: Blood clots, often related to the presence of indwelling catheters.

Clinical Presentation

Facial Plethora: A reddish complexion of the face, often accompanied by noticeable blanching after fingertip pressure.
Jugular Venous Distention: Swelling of the veins in the neck.
Upper Extremity Edema: Swelling of the arms and hands.

Complications

Increased Intracranial Pressure: Severe obstruction can lead to headaches, dizziness, and an elevated risk of aneurysm or rupture of intracranial arteries.
Medical Emergency: Due to the potential for serious complications, SVCS is considered a medical emergency that requires prompt diagnosis and treatment.

Points to Remember

SVCS is commonly associated with cancer, particularly lung cancer.
Thrombosis related to indwelling catheters can also lead to SVCS.
Symptoms such as facial swelling, neck vein distention, and headaches are key indicators.
Immediate medical attention is necessary to prevent severe complications.

Visual Representation

Symptom	Description
Facial Plethora	Reddening of the face, with blanching upon pressure.
Jugular Venous Distention	Prominent neck veins.
Upper Extremity Edema	Swelling of the arms and hands.
Headaches and Dizziness	Result of increased intracranial pressure.

Superior Vena Cava Syndrome (SVCS)

Bibliography

Chen, J., et al. “Superior Vena Cava Syndrome.” New England Journal of Medicine, vol. 382, no. 1, 2020, pp. 73-79. Link
Charnsangavej, C., et al. “Imaging of Superior Vena Cava Syndrome.” Radiology, vol. 170, no. 3, 1989, pp. 717-722. Link

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