U01.17.036 Hyper-IgM Syndrome (CD40L Defect)
Study this flashcard to identify the genetic defect, immunologic mechanism, and clinical consequences of Hyper-IgM Syndrome. Recall how a CD40L mutation on T cells prevents class switching, leading to elevated IgM levels with low IgG, IgA, and IgE, and recurrent bacterial and opportunistic infections.
Question categories All Questions, U01.17 Review condition and pathophysiology, USMLE Step 1 Review Series
Question tags antibody class switching, CD40 ligand mutation, CD40L defect, class switching defect, high IgM, Hyper-IgM review, Hyper-IgM syndrome, immune system disorder, immunodeficiency, immunology, low IgA, low IgE, low IgG, Medical Flashcards, opportunistic infections, Recurrent Infections, T cell-B cell interaction, USMLE Step 1, X-linked immunodeficiency
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