U01.21.030 Filtration Fraction (FF)

Learning Objective:
Understand and calculate Filtration Fraction (FF) — the proportion of plasma that is filtered through the glomerulus.


Formula:

FF = \frac{GFR}{RPF}


Explanation:

  • FF = Filtration Fraction
  • GFR = Glomerular Filtration Rate
  • RPF = Renal Plasma Flow

It represents the fraction of renal plasma flow that becomes glomerular filtrate.


Concept Summary:

  • Normal FF ≈ 20% (i.e., ~20% of plasma entering glomeruli is filtered).
  • Changes in afferent/efferent arteriolar tone can alter FF:
    • ↑ Efferent constriction → ↑ GFR → ↑ FF
    • ↑ Afferent constriction → ↓ GFR → ↓ FF

Example:

Given:
GFR = 120 \text{ mL/min}
RPF = 600 \text{ mL/min}

FF = \frac{120}{600} = 0.2 = 20%

Answer: Filtration Fraction = 20%


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